Ethyl 7-chloro-2-oxoheptanoate, identified by its CAS number 78834-75-0, stands out as a versatile and essential compound within the fine chemical and pharmaceutical industries. This article aims to explore its fundamental chemical properties, significant applications, and the methods employed in its synthesis and purification.

Chemically, Ethyl 7-chloro-2-oxoheptanoate possesses the molecular formula C9H15ClO3 and a molecular weight of approximately 206.67 g/mol. It typically presents as a clear liquid, ranging in color from light green to pale yellow. Key physical properties include a boiling point of around 281.2°C at standard atmospheric pressure and a density of approximately 1.093 g/cm³. Its solubility in common organic solvents like acetonitrile, chloroform, and ethyl acetate makes it amenable to a variety of chemical reactions. The compound's refractive index, typically measured between 1.4510 and 1.4560, is another important characteristic for quality control.

The primary utility of Ethyl 7-chloro-2-oxoheptanoate lies in its role as a pharmaceutical intermediate. Its most recognized application is in the synthesis of Cilastatin, a critical component used in combination with Imipenem for treating severe bacterial infections. The meticulous synthesis of cilastatin sodium often involves this precursor, highlighting the need for a reliable source for ethyl 7-chloro-2-oxoheptanoate. Furthermore, this compound serves as a building block for other complex organic molecules, including certain cancer therapeutics like selective BCL-XL inhibitors, demonstrating its broader significance in drug discovery.

The successful production of high-purity Ethyl 7-chloro-2-oxoheptanoate involves sophisticated synthesis and purification techniques. While various methods exist, the goal is always to achieve excellent yields and minimal impurities, ensuring the compound's suitability for pharmaceutical applications. Understanding the parameters for the cilastatin sodium synthesis process, which often specifies the use of this intermediate, is crucial for manufacturers. For researchers and companies seeking to procure this chemical, identifying suppliers that offer ethyl 7-chloro-2-oxoheptanoate with a purity specification of greater than 98.0% is paramount.

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