The responsible use of chemical compounds in laboratory and industrial settings is paramount. Ethyl 7-chloro-2-oxoheptanoate (CAS: 78834-75-0), a valuable pharmaceutical intermediate, requires careful handling to ensure the safety of personnel and the integrity of the working environment.

Ethyl 7-chloro-2-oxoheptanoate, while crucial for synthesizing drugs like Cilastatin, possesses certain hazardous properties that necessitate strict adherence to safety protocols. According to GHS classifications, it is typically labeled as harmful if swallowed, inhaled, or in contact with skin. It can also cause skin and eye irritation, and potentially respiratory tract irritation. Therefore, comprehensive safety measures must be implemented during its storage, handling, and use.

Key safety recommendations for working with Ethyl 7-chloro-2-oxoheptanoate include:

  • Personal Protective Equipment (PPE): Always wear appropriate PPE, including chemical-resistant gloves (e.g., nitrile, neoprene), safety goggles or a face shield, and protective clothing such as lab coats or aprons.
  • Ventilation: Ensure adequate ventilation in the workspace. Handling should ideally occur in a fume hood to minimize exposure to vapors or airborne particles.
  • Handling Procedures: Avoid direct contact with skin, eyes, and clothing. Do not inhale vapors or mist. Wash hands thoroughly after handling the substance, especially before eating, drinking, or smoking.
  • Storage: Store the compound in a cool, dry, and well-ventilated area, away from incompatible materials. Keep containers tightly closed to prevent moisture absorption and contamination. Recommended storage temperatures are often between 2-8°C, under an inert atmosphere for optimal stability.
  • Emergency Procedures: In case of exposure, immediately seek medical attention. If contact occurs with skin, wash thoroughly with soap and water. For eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. If inhaled, move the person to fresh air and keep them at rest.

Understanding the physical and chemical properties of ethyl 7-chloro-2-oxoheptanoate, such as its solubility and flash point, can also inform safer handling practices. For instance, knowing its flash point helps in assessing fire risks. While the synthesis of cilastatin intermediate is a critical process, safety must always be the top priority.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality products alongside essential safety information. We believe that informed handling is key to successful and safe chemical operations. We encourage all users to consult the Material Safety Data Sheet (MSDS) for Ethyl 7-chloro-2-oxoheptanoate before use and to follow all relevant local safety regulations.