A thorough understanding of chemical properties is fundamental for the effective utilization of any compound, especially within the rigorous demands of the pharmaceutical industry. NINGBO INNO PHARMCHEM CO.,LTD. provides Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate (CAS 161798-02-3), a critical Febuxostat intermediate, and offers insight into its key chemical characteristics. These properties are crucial for process optimization, quality assurance, and ensuring the integrity of downstream synthetic processes.

Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate is characterized by its specific molecular formula, C14H12N2O3S, and a molecular weight of 288.32 g/mol. These fundamental identifiers are essential for stoichiometric calculations in chemical reactions. The compound typically presents as an off-white powder, a visual cue that is often checked as part of the initial quality assessment. Its melting point is notably high, generally reported in the range of 208-210°C, which is indicative of a stable solid structure at room temperature and suggests a certain degree of thermal stability during handling and processing.

Solubility is another critical property that dictates how a compound can be effectively used in synthesis. While specific solubility data can vary, this thiazole derivative is generally reported to have slight solubility in common organic solvents like DMSO and methanol. This characteristic is important for selecting appropriate reaction media and purification solvents. Understanding these solubility profiles allows chemists to design efficient reaction pathways and purification methods, ensuring the successful synthesis of Febuxostat. The ability to purchase materials with well-defined solubility parameters aids significantly in process development.

The compound also possesses a pKa value, approximately 5.80 ± 0.20, which indicates its acidic nature and the pH at which it will be half-ionized. This information is valuable when considering reactions involving acid-base chemistry or when formulating the compound in specific pH environments. Furthermore, its chemical structure, featuring a thiazole ring, a cyano group, a hydroxyl group, and an ethyl ester, provides reactive sites that are leveraged in the multi-step synthesis of Febuxostat. Each functional group plays a specific role in the molecular transformations required.

NINGBO INNO PHARMCHEM CO.,LTD. ensures that detailed technical specifications, including these chemical properties, are readily available to our clients. This transparency empowers our customers to make informed decisions regarding the application of Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate in their specific research and manufacturing processes. Our commitment to providing comprehensive product information supports efficient buy and utilization strategies for this important intermediate.