2-Bromo-4-fluoroaniline, identified by its CAS number 1003-98-1, is a fine chemical characterized by its aromatic structure featuring strategically placed halogen substituents and an amine group. Its molecular formula, C6H5BrFN, and molecular weight of approximately 190.01 g/mol provide insight into its composition. Typically appearing as a transparent liquid, its specific color can range from light yellow to brown, depending on purity and storage conditions. The compound exhibits a density of around 1.67 g/mL at 25°C, and its boiling point is approximately 221°C, indicating a relatively stable liquid at room temperature.

The chemical reactivity of 2-Bromo-4-fluoroaniline is largely governed by its functional groups. The amine group (-NH2) is nucleophilic and can readily undergo reactions such as acylation, alkylation, and diazotization. The bromine atom (-Br) serves as an excellent leaving group in nucleophilic aromatic substitution reactions and is particularly valuable in transition metal-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura or Buchwald-Hartwig amination. The fluorine atom (-F), due to its high electronegativity, influences the electronic distribution within the aromatic ring, potentially affecting the reactivity of other positions and imparting specific properties like increased lipophilicity or metabolic stability to molecules derived from it.

While specific synthesis routes are proprietary, general methods for producing such compounds often involve the bromination of 4-fluoroaniline or the reduction of a corresponding nitro compound. For instance, 4-fluoroaniline can be subjected to bromination under controlled conditions to selectively introduce the bromine atom at the ortho position. Alternatively, a 2-bromo-4-fluoronitrobenzene derivative could be reduced to yield the desired aniline. Ningbo Inno Pharmchem Co., Ltd. specializes in producing high-purity 2-Bromo-4-fluoroaniline, ensuring that manufacturers have access to a reliable and consistent supply for their demanding applications. Understanding the synthesis and chemical properties of this intermediate is key for anyone looking to buy 2-Bromo-4-fluoroaniline for their research or manufacturing processes.