2-Chloronicotinic acid (CAS 2942-59-8) is a chemical compound of significant interest due to its versatile applications as an intermediate in various industries, particularly pharmaceuticals and agrochemicals. Understanding its chemical properties and synthesis routes is crucial for researchers and manufacturers. NINGBO INNO PHARMCHEM CO.,LTD. provides insights into these critical aspects of this important chemical.

Chemically, 2-Chloronicotinic acid has the molecular formula C6H4ClNO2 and a molecular weight of approximately 157.55. It is typically described as a white to cream-colored powder. Its melting point is generally reported in the range of 176-178°C, often with decomposition. The compound exhibits solubility in organic solvents such as DMSO and Ethyl Acetate, but is sparingly soluble in water. Its pKa value is around 2.07 ± 0.25, indicating its acidic nature. These properties are fundamental for designing reaction conditions and purification processes when working with this compound.

The synthesis of 2-Chloronicotinic acid often involves multi-step chemical reactions, starting from precursor materials. While specific proprietary methods may vary among manufacturers, common approaches involve chlorination and oxidation reactions applied to nicotinic acid derivatives. For instance, one synthesis pathway might involve using nicotinic acid N-oxide, reacting it with chlorinating agents like phosphorus oxychloride and phosphorus pentachloride under controlled temperature conditions. Achieving high purity, often exceeding 99%, is a key objective in these synthesis processes, ensuring the compound's suitability for demanding applications. Those seeking to buy 2-Chloronicotinic acid should inquire about the purity and any associated analytical data.

The availability of detailed analytical data, such as CAS registry information (CAS 2942-59-8) and spectral data (like NMR and MS, although not detailed here), is essential for quality control and research. The uses of 2-Chloronicotinic acid are directly linked to its chemical structure and reactivity, making it a valuable intermediate for crafting complex organic molecules. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying researchers and manufacturers with precise and high-quality 2-Chloronicotinic acid, facilitating innovation across the chemical landscape.