At NINGBO INNO PHARMCHEM CO.,LTD., we pride ourselves on delivering high-quality chemical products that drive innovation across industries. Among our key offerings is 2-Ethoxybenzoic acid (CAS 134-11-2), a compound whose chemical properties and synthesis are central to its wide applicability. This article will provide an in-depth look at what makes 2-Ethoxybenzoic acid a valuable commodity in the chemical market.

Chemically speaking, 2-Ethoxybenzoic acid is an ortho-substituted benzoic acid derivative. Its IUPAC name is 2-ethoxybenzoic acid, and it possesses the molecular formula C9H10O3 with a molecular weight of 166.18 g/mol. The presence of both a carboxylic acid group (-COOH) and an ethoxy group (-OCH2CH3) on the benzene ring dictates its reactivity and solubility characteristics. It is typically described as a white crystalline powder with a melting point in the range of 63-65°C. This specific physical state and melting point are crucial for quality control and processing.

When considering the chemical properties of 2-ethoxybenzoic acid, its solubility is a key factor. It is soluble in ethanol and ether, which are common organic solvents used in synthesis and purification. While slightly soluble in water, its affinity for organic media makes it highly useful in reactions requiring non-aqueous environments. Its pKa value of approximately 4.21 indicates it is a weak acid, typical for benzoic acid derivatives.

The synthesis of 2-Ethoxybenzoic acid can be achieved through several routes, often involving the esterification or modification of salicylic acid derivatives. A common method involves the O-alkylation of salicylic acid or its esters with an ethylating agent, followed by hydrolysis if an ester intermediate is used. For instance, methyl salicylate can be reacted with ethyl iodide in the presence of a base, followed by hydrolysis of the resulting ester to yield 2-Ethoxybenzoic acid. Understanding these synthetic pathways is crucial for optimizing production for both yield and purity. The process requires careful control of reaction conditions, including temperature, reaction time, and the choice of reagents and solvents, to minimize side reactions and maximize the output of the desired product.

Ensuring the purity and quality of 2-Ethoxybenzoic acid is paramount, especially when it is to be used as a pharmaceutical intermediate. NINGBO INNO PHARMCHEM employs stringent quality control measures throughout the production process. Techniques such as High-Performance Liquid Chromatography (HPLC) are used to verify purity, typically ensuring it meets specifications of ≥98% (HPLC). Gas Chromatography-Mass Spectrometry (GC-MS) can also be employed for detailed analysis of any potential impurities.

The compound’s utility as an organic synthesis building block is further enhanced by its predictable reactivity. The carboxylic acid group can undergo esterification, amidation, and reduction, while the aromatic ring can participate in electrophilic substitution reactions, although the ethoxy group’s presence influences regioselectivity. These reactions allow chemists to incorporate the 2-ethoxybenzoyl moiety into a wide array of complex molecules, supporting innovation in drug discovery, materials science, and beyond.

In summary, the chemical properties and controlled synthesis of 2-Ethoxybenzoic acid are fundamental to its value in the chemical industry. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing a reliable supply of this essential compound, backed by robust quality assurance. Whether for pharmaceutical synthesis, agrochemical development, or as a general organic building block, understanding these aspects ensures successful application and further research.