Understanding the chemical nuances of key research compounds is fundamental to successful scientific endeavors. Boc-Ser(tBu)-OH (CAS: 13734-38-8), a protected derivative of the amino acid serine, is a prime example of such a compound. Its chemical structure and properties make it highly valuable in advanced biochemical research, particularly in the synthesis of peptides and complex organic molecules.

The synthesis of Boc-Ser(tBu)-OH typically involves protecting the amino group of L-serine with a tert-butoxycarbonyl (Boc) group and the hydroxyl group with a tert-butyl (tBu) ether. This dual protection strategy is crucial, as it allows for selective reactions to occur at other parts of a molecule without interference from the highly reactive amino and hydroxyl groups of serine. Several synthesis routes exist, often starting from L-serine, with careful control of reaction conditions to ensure high purity and stereochemical integrity. The optimization of these preparation methods is an ongoing effort by manufacturers to provide researchers with the highest quality materials, ensuring reproducible experimental outcomes.

In terms of its chemical properties, Boc-Ser(tBu)-OH is typically described as a light yellowish oil. Its solubility in organic solvents like DMF and DCM makes it amenable to standard laboratory procedures. The stability of the Boc and tBu protecting groups under various conditions is a significant advantage, allowing for its incorporation into diverse synthetic strategies without premature cleavage. This reliability is essential for complex multi-step syntheses, where protecting group management is a critical factor.

The scientific research applications of Boc-Ser(tBu)-OH are extensive. It is widely used in Solid-Phase Peptide Synthesis (SPPS) to build peptide chains, which are crucial for studying enzyme mechanisms, protein-protein interactions, and developing therapeutic peptides. Its ability to be selectively deprotected allows for controlled elongation of the peptide backbone. Furthermore, its use in custom synthesis projects enables the creation of modified peptides with specific biological activities, such as those explored for neurotrophic or antimicrobial effects. The consistent supply of this compound from sources like NINGBO INNO PHARMCHEM CO.,LTD. is vital for the continuous progress in these research fields.

The careful handling and storage of Boc-Ser(tBu)-OH are also important to maintain its integrity. Typically stored under dry conditions at cool temperatures (2-8°C), it remains stable for extended periods. This attention to storage conditions, coupled with stringent quality control measures by suppliers, ensures that the compound's properties are preserved, making it a reliable reagent for critical research applications. As biochemical research continues to advance, the demand for such precisely engineered chemical intermediates will remain high, underscoring the value of compounds like Boc-Ser(tBu)-OH.