In the field of organic chemistry, the synthesis and application of specialized molecules are key drivers of innovation, particularly in pharmaceutical research and fine chemical manufacturing. 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile, identified by its CAS number 1240948-77-9, is a compound that embodies this principle, offering significant utility as both a synthetic intermediate and an analytical reference. Understanding its synthesis and application spectrum provides valuable insights into its importance.

The synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile typically involves established heterocyclic chemistry methodologies. While specific proprietary routes may vary, common approaches often start with readily available precursors and employ cyclization and functionalization reactions. For instance, methods might involve the condensation of appropriately substituted carbonyl compounds or enolates with nitrogen sources to form the pyrrole ring, followed by the introduction of the nitrile and fluorophenyl groups through specific chemical transformations. The careful control of reaction conditions is paramount to achieving high yields and purity, which is essential for its intended uses.

As a versatile building block in organic synthesis, 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile offers multiple reactive sites. The nitrile group can undergo reduction to an amine, hydrolysis to a carboxylic acid, or participate in cycloaddition reactions. The pyrrole nitrogen can be alkylated or acylated, and the aromatic rings can undergo electrophilic substitution. These functionalities allow chemists to efficiently construct a wide array of more complex molecules, making it a sought-after intermediate in the synthesis of novel organic compounds and potential drug candidates. For companies looking to advance their R&D, securing a reliable source for this compound, i.e., to buy 5-(2-fluorophenyl)-1h-pyrrole-3-carbonitrile, is a strategic step.

Furthermore, its role as an analytical standard is critical in ensuring the quality and safety of pharmaceutical products. In the context of Vonoprazan, a medication used for gastrointestinal disorders, 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile has been identified as a related substance or impurity. Accurate quantification and control of such impurities are mandated by regulatory authorities. Therefore, having access to high-purity 5-(2-fluorophenyl)-1h-pyrrole-3-carbonitrile as a reference material allows for precise method development and validation in quality control laboratories. This ensures that the final drug products meet rigorous safety and efficacy standards.

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In summary, the chemical synthesis and diverse applications of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile underscore its significance in the chemical industry. From its role in intricate synthetic pathways to its crucial function in analytical testing, this compound is a testament to the power of targeted chemical design and reliable sourcing.