At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in providing high-quality chemical intermediates that are crucial for innovation in organic chemistry and pharmaceutical development. Methyl 3-Bromo-4-fluorobenzoate (CAS: 82702-31-6) is a prime example of such a versatile compound, offering a unique combination of a methyl ester, a bromine atom, and a fluorine atom on an aromatic ring. This structural arrangement makes it an exceptionally useful building block for synthesizing a wide array of complex organic molecules.

The synthesis of Methyl 3-Bromo-4-fluorobenzoate typically involves the esterification of 3-Bromo-4-fluorobenzoic acid. This process, often carried out using methanol in the presence of an acid catalyst, is optimized by NINGBO INNO PHARMCHEM CO.,LTD. to achieve high yields and purity. The resulting compound, usually presented as an off-white powder, possesses a purity of 97% or higher, ensuring its reliability for demanding synthetic applications.

The true power of Methyl 3-Bromo-4-fluorobenzoate lies in its diverse chemical reactivity and its numerous 3-bromo-4-fluorobenzoic acid methyl ester uses. The bromine substituent is an excellent leaving group and is highly amenable to various metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Heck couplings. These reactions allow for the efficient introduction of carbon-carbon bonds, enabling the construction of complex aromatic and heteroaromatic systems that are foundational in many pharmaceutical compounds. For example, coupling with appropriate boronic acids can lead to the formation of biaryl systems that are common motifs in active pharmaceutical ingredients (APIs).

The presence of the fluorine atom also contributes significantly to the utility of this intermediate. Fluorine substitution can profoundly impact the physical, chemical, and biological properties of a molecule. It often enhances lipophilicity, which can improve cell membrane permeability and oral bioavailability of drugs. Moreover, the strong carbon-fluorine bond can increase metabolic stability, extending the half-life of a drug in the body. This makes fluorinated compounds, and therefore intermediates like Methyl 3-Bromo-4-fluorobenzoate, highly prized in medicinal chemistry.

As leading pharmaceutical intermediates suppliers, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to empowering researchers by providing them with the highest quality chemical tools. When you choose to buy Methyl 3-Bromo-4-fluorobenzoate from us, you are assured of a product that meets rigorous quality standards, facilitating successful methyl 3-bromo-4-fluorobenzoate synthesis and downstream applications. Trust NINGBO INNO PHARMCHEM CO.,LTD. to be your reliable partner in chemical innovation.