Understanding the fundamental chemistry of essential compounds is crucial for any chemist. NINGBO INNO PHARMCHEM CO.,LTD. sheds light on the chemical properties and synthesis methods of 2-Bromopyridine (CAS: 109-04-6), a versatile intermediate widely used in various chemical applications.

2-Bromopyridine is an organobromine compound and a derivative of pyridine, characterized by a bromine atom attached to the second position of the pyridine ring. Its molecular formula is C5H4BrN, and it has a molecular weight of approximately 158.00 g/mol. Physically, it is typically described as a clear to pale brown liquid with a density of around 1.657 g/mL at 25°C. It possesses a boiling point of approximately 192-194°C and a refractive index of n20/D 1.572, indicating its characteristic liquid state under standard conditions. Its solubility in water is limited, but it is generally miscible with common organic solvents.

The synthesis of 2-Bromopyridine often involves the bromination of 2-aminopyridine. A common industrial method entails the diazotization of 2-aminopyridine followed by bromination. This process typically involves treating 2-aminopyridine with hydrobromic acid and liquid bromine under controlled low temperatures, often below -5°C, to manage the exothermic reaction and maximize yield. Subsequent steps may include neutralization, extraction with an organic solvent, washing, drying, and vacuum distillation to isolate the pure 2-Bromopyridine. This method, while effective, requires careful temperature control and handling of hazardous reagents.

The chemical reactivity of 2-Bromopyridine stems from the electronegativity of the bromine atom and the electron-deficient nature of the pyridine ring. This makes it susceptible to nucleophilic aromatic substitution reactions, where the bromine can be displaced. It also readily participates in various metal-catalyzed cross-coupling reactions, which are foundational in modern organic synthesis for forming new carbon-carbon and carbon-heteroatom bonds. These reactions are key to constructing complex molecular architectures required in pharmaceutical and agrochemical industries.

NINGBO INNO PHARMCHEM CO.,LTD. ensures that the 2-Bromopyridine supplied meets high standards of purity and consistency, which is vital for its performance in these sensitive chemical transformations. Understanding these chemical properties and synthesis routes allows chemists to effectively utilize this intermediate in their research and production, driving innovation and achieving desired outcomes in their chemical projects.