The development of advanced pharmaceuticals often hinges on the intricate pathways of organic synthesis, where specific chemical intermediates play pivotal roles. For the groundbreaking cardiovascular drug Sacubitril, tert-butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate stands out as a crucial precursor. This compound, identified by its CAS number 1426129-50-1 and possessing the molecular formula C20H25NO3, is fundamental to the effective synthesis of Sacubitril, a vital medication used in combination therapy for heart failure.

The synthesis of complex chiral molecules like Sacubitril requires intermediates with precisely defined stereochemistry and high chemical purity. Tert-butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate fulfills these requirements. Its structure incorporates the biphenyl group and a protected amino alcohol moiety, which are essential for the subsequent chemical transformations leading to the final API. The carbamate protecting group on the amino function is strategically placed to allow for controlled deprotection and further reactions in the synthesis route.

The physical properties of this intermediate, such as its appearance as a white or off-white powder and a melting point typically between 114-116 °C, are indicators of its purity and crystalline form. Manufacturers rely on these characteristics, alongside stringent analytical testing, to ensure the quality of the intermediate used in their processes. The demand for high-purity pharmaceutical intermediates is driven by the need to produce APIs that meet global regulatory standards, ensuring patient safety and therapeutic efficacy.

Beyond its role in Sacubitril, the structural features of tert-butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate make it a valuable compound for various applications in organic synthesis and medicinal chemistry research. Its availability from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. empowers researchers to explore new synthetic routes and discover novel therapeutic agents. The focus on providing such intermediates at competitive prices underscores the company's commitment to supporting pharmaceutical innovation.

In essence, understanding the chemistry and supply chain of critical intermediates like tert-butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate is vital for the successful production of modern medicines. NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to this process by offering high-quality chemical solutions for the pharmaceutical industry.