The precise understanding of chemical compounds is the bedrock of pharmaceutical innovation. 3-Methylflavone-8-carboxylic acid (CAS 3468-01-7) is one such compound, a molecule that holds significant importance as a pharmaceutical intermediate and a metabolite of therapeutic agents. Its chemical structure, properties, and synthesis are key areas of interest for researchers and manufacturers in the chemical industry.

Chemically, 3-Methylflavone-8-carboxylic acid is classified as a flavone derivative. Its molecular formula is C17H12O4, with a molecular weight of approximately 280.27 g/mol. The compound typically presents as a white crystalline solid, with a defined melting point range of 234-236°C, indicating a high degree of purity and crystalline structure. This characteristic solid form is advantageous for handling, storage, and formulation purposes in the pharmaceutical sector. Its solubility profile indicates limited solubility in water but better solubility in organic solvents like DMSO and methanol, which is typical for compounds of this nature and influences its use in various chemical reactions and analytical techniques.

The synthesis of 3-Methylflavone-8-carboxylic acid involves multi-step chemical processes. While specific proprietary synthesis routes are often guarded by manufacturers, common approaches in organic chemistry for constructing flavone skeletons often involve cyclization reactions and functional group manipulations. The introduction of the methyl group at the 3-position and the carboxylic acid group at the 8-position requires careful control of reaction conditions and reagent selection. Efficient 3-Methylflavone-8-carboxylic acid synthesis is crucial for its availability as a research chemical and as a key intermediate for further drug development. The pursuit of optimized synthesis pathways aims to improve yields, reduce impurities, and lower production costs.

Beyond its physical properties, the chemical reactivity of the carboxylic acid group and the flavone backbone allows for diverse chemical transformations. This makes 3-Methylflavone-8-carboxylic acid a versatile intermediate in the synthesis of various pharmaceuticals. Its role as a metabolite of Flavoxate also provides valuable insights into the pharmacokinetics of the parent drug and the potential biological activities of its breakdown products. The phosphodiesterase (PDE) inhibitory activity is a key chemical property that translates into biological effects, influencing smooth muscle function and making it a target for further pharmacological investigation. The ongoing study of its chemical characteristics, including its antioxidant and anti-inflammatory potential, further broadens its significance in the field of medicinal chemistry. As a well-defined chemical entity, 3-Methylflavone-8-carboxylic acid continues to be a focal point for research, contributing to the advancement of pharmaceutical sciences through its chemistry and applications.