NINGBO INNO PHARMCHEM CO.,LTD. offers a comprehensive portfolio of Hypromellose (HPMC) grades, empowering pharmaceutical manufacturers to achieve optimal results in their formulations. Selecting the correct HPMC grade is crucial, as different grades possess distinct properties that influence everything from tablet compressibility to drug release rates. This guide aims to clarify the key considerations when you need to buy HPMC for pharmaceutical excipients.

The primary factors to consider when choosing an HPMC grade are its viscosity and its intended application. Viscosity, typically measured in a 2% aqueous solution at 20°C, is a critical parameter, especially for controlled-release applications. For instance, higher viscosity HPMC grades (e.g., K100M, K150M, K200M) are generally preferred for creating robust hydrophilic matrices that slow down drug release. Conversely, lower viscosity grades (e.g., E3, E5, E6) might be suitable for applications where rapid dissolution is desired or as film-coating agents where less thickening power is needed.

For pharmaceutical excipients, different substitution patterns also play a role. The E-grades (e.g., E4M, E50) and K-grades (e.g., K4M, K15M, K100M) denote variations in the hydroxypropyl and methoxy content, which can affect properties like thermal gelation temperature and solubility in different solvents. Understanding these nuances is vital for tailoring the excipient to specific formulation challenges. For example, when formulating for specific pH environments or requiring certain dissolution characteristics, the choice of grade can significantly impact performance.

When developing hard shell capsules, our Pharma Grade HPMC offers excellent film-forming properties and is a stable, vegan alternative to gelatin. For tablet manufacturing, the directly compressible (DC) grades of HPMC can simplify production processes by enabling direct compression, reducing manufacturing time and costs. NINGBO INNO PHARMCHEM CO.,LTD. provides detailed technical data sheets for each HPMC grade, including specifications for viscosity, purity, and other relevant parameters. Our expert team is available to guide you through the selection process, ensuring you choose the most effective HPMC for your drug delivery system.