The Critical Link: Understanding 1-(2,3-Dichlorophenyl)piperazine Hydrochloride in Aripiprazole Production
The journey of a pharmaceutical drug from conception to patient care involves numerous intricate steps, with the synthesis of the Active Pharmaceutical Ingredient (API) being one of the most critical. Within this synthesis, chemical intermediates act as essential bridge compounds. 1-(2,3-Dichlorophenyl)piperazine hydrochloride stands out as a particularly important intermediate, primarily due to its indispensable role in the production of Aripiprazole, a groundbreaking medication for treating severe mental health disorders.
Aripiprazole, known for its efficacy in managing symptoms of schizophrenia, bipolar disorder, and depression, requires a precise chemical structure that is built step-by-step. 1-(2,3-Dichlorophenyl)piperazine hydrochloride is a key precursor that provides a significant portion of this molecular framework. Its specific chemical structure and reactivity are carefully engineered to facilitate subsequent reactions, leading to the final Aripiprazole molecule. The compound's chemical name, CAS number (119532-26-2), molecular formula (C10H13Cl3N2), and molecular weight (267.58300) all signify the precise nature of pharmaceutical chemistry.
The physical characteristics of 1-(2,3-Dichlorophenyl)piperazine hydrochloride are also crucial for its industrial application. Typically appearing as a white or off-white powder, it possesses a high melting point (245-247°C), indicating its stability under various processing conditions. This stability, coupled with a purity level of at least 99%, ensures that manufacturers can rely on its performance in complex synthesis pathways, minimizing the risk of unwanted side reactions or impurities in the final drug product.
Companies focusing on the production of such vital intermediates, like NINGBO INNO PHARMCHEM CO.,LTD., adhere to strict quality control protocols. Their commitment to providing reliable API intermediates ensures that pharmaceutical companies globally have access to the necessary materials for producing life-changing medications. For those seeking to understand the manufacturing intricacies, exploring high purity pharmaceutical intermediates and understanding the importance of specific chemical properties for Aripiprazole synthesis provides valuable insight into the pharmaceutical industry's backbone.
In essence, 1-(2,3-Dichlorophenyl)piperazine hydrochloride is more than just a chemical compound; it is a critical link in the chain that brings effective treatments for mental health conditions to patients. Its precise properties and consistent availability are foundational to the successful manufacturing of Aripiprazole, highlighting the profound impact of specialized chemical intermediates on global healthcare.
Perspectives & Insights
Alpha Spark Labs
“Its specific chemical structure and reactivity are carefully engineered to facilitate subsequent reactions, leading to the final Aripiprazole molecule.”
Future Pioneer 88
“The compound's chemical name, CAS number (119532-26-2), molecular formula (C10H13Cl3N2), and molecular weight (267.”
Core Explorer Pro
“The physical characteristics of 1-(2,3-Dichlorophenyl)piperazine hydrochloride are also crucial for its industrial application.”