Fmoc-Glycine, scientifically identified as Nα-Fmoc-L-glycine with CAS number 29022-11-5, is a vital organic intermediate that plays a pivotal role in numerous scientific disciplines, most notably in peptide synthesis and pharmaceutical development. As a derivative of glycine, the simplest of the amino acids, Fmoc-Glycine offers unique advantages due to its achiral nature and the strategic presence of the Fmoc protecting group. This article aims to demystify Fmoc-Glycine by exploring its essential properties, its diverse applications, and the manufacturing processes that bring this crucial compound to market, with insights from leading manufacturers like NINGBO INNO PHARMCHEM CO.,LTD.

The physical and chemical properties of Fmoc-Glycine make it an ideal reagent for complex synthesis. It typically presents as a white to off-white powder with a molecular formula of C17H15NO4 and a molecular weight of approximately 297.3 g/mol. Its melting point usually falls within the range of 174-185°C, indicating good thermal stability for most laboratory procedures. Crucially, Fmoc-Glycine exhibits solubility in common organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), which are frequently employed in peptide coupling reactions. The Fmoc group, a base-labile protecting group, is selectively removable under mild conditions, facilitating controlled peptide chain elongation without compromising the integrity of the peptide backbone. This controlled reactivity is fundamental for achieving high yields and purities in synthesis.

The applications of Fmoc-Glycine are extensive and critical for modern scientific advancements. Its primary use is in the solid-phase peptide synthesis (SPPS) of biologically active peptides, which are crucial components in drug discovery for conditions ranging from cancer to metabolic disorders. Fmoc-Glycine serves as a key building block, enabling the step-by-step construction of peptide sequences with high fidelity. Beyond therapeutic applications, it is utilized in biochemical research to study protein structure, enzyme activity, and the development of novel diagnostic assays. The demand for high-quality Fmoc-Glycine necessitates reliable sourcing from experienced manufacturers. Companies specializing in the production of fine chemicals and pharmaceutical intermediates, such as NINGBO INNO PHARMCHEM CO.,LTD., ensure that researchers have access to products meeting stringent purity specifications, often exceeding 99% via HPLC. This focus on quality is vital for obtaining reproducible research results and developing safe and effective pharmaceutical products.

The manufacturing of Fmoc-Glycine typically involves the reaction of glycine with 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) in the presence of a base. The process requires careful control of reaction conditions to maximize yield and minimize impurities. Purification methods, such as recrystallization or chromatography, are employed to achieve the high purity levels demanded by the industry. The robust manufacturing capabilities in China, particularly from suppliers like NINGBO INNO PHARMCHEM CO.,LTD., have made high-quality Fmoc-Glycine more accessible globally. These manufacturers adhere to strict quality control protocols, ensuring lot-to-lot consistency and compliance with international standards. When looking to purchase Fmoc-Glycine, it is advisable to consider suppliers who offer comprehensive documentation and technical support, guaranteeing the integrity of the product.

In summary, Fmoc-Glycine (CAS 29022-11-5) is an indispensable reagent whose unique chemical properties and applications are fundamental to advancements in peptide synthesis and pharmaceutical research. Its role as a high-purity building block, combined with reliable manufacturing and supply, underscores its importance in scientific innovation. NINGBO INNO PHARMCHEM CO.,LTD. remains a key player in providing this critical compound, ensuring researchers and industries have the tools they need to drive progress.