NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing comprehensive insights into the chemicals we supply, and Ethyl (ethoxymethylene)cyanoacetate (CAS 94-05-3), or EMCA, is a prime example of a compound with fascinating chemical characteristics and synthesis pathways.

The synthesis of EMCA is a subject of considerable chemical literature, with several routes yielding high-purity product. A prominent method involves the acid-catalyzed condensation of ethyl cyanoacetate with triethyl orthoformate. This reaction, often carried out in solvents like isopropyl alcohol at controlled temperatures, is a cornerstone for industrial production. Variations exist, such as using different catalysts or reaction conditions, each aiming to optimize yield and purity. The precision in ethyl (ethoxymethylene)cyanoacetate synthesis is crucial for its downstream applications.

Understanding the physical and chemical properties of EMCA is equally important. Typically appearing as a white to light yellow solid, it has a defined melting point of around 49-51 °C and a boiling point of approximately 190-191 °C at reduced pressure. These properties, readily available from sources like BenchChem and PubChem, guide its handling, storage, and application in various chemical reactions. The chemical structure, C8H11NO3, with its reactive cyano and ethoxymethylene groups, dictates its role as a versatile building block.

Analytical methods for verifying the purity and structure of EMCA are robust. Techniques such as High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) are routinely employed to confirm its assay, often exceeding 98.0%. Spectroscopic methods, including NMR and IR, are used to validate its molecular structure, ensuring it meets stringent quality standards. These analytical insights, often detailed in supplier specifications, are critical for researchers and manufacturers relying on the integrity of this chemical intermediate.

Safety protocols are also paramount when handling EMCA. Like many fine chemicals, it requires careful handling to avoid skin, eye, or respiratory irritation. Adherence to GHS hazard classifications and proper use of personal protective equipment are essential for safe laboratory and industrial practices. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes these safety considerations in all its product information.

By providing access to high-quality EMCA and detailed information on its synthesis and properties, NINGBO INNO PHARMCHEM CO.,LTD. supports scientific advancement and industrial innovation.