NINGBO INNO PHARMCHEM CO.,LTD. is proud to offer Domperidone Maleate (CAS: 99497-03-7), a versatile pharmaceutical intermediate with applications ranging from gastrointestinal relief to lactation support. This article delves into the dual roles of Domperidone Maleate, highlighting its benefits and considerations for both uses.

Primarily, Domperidone Maleate is known for its antiemetic and prokinetic properties. It effectively manages nausea and vomiting by acting on dopamine receptors in the brain's CTZ, offering a solution with fewer central side effects compared to other dopamine antagonists. This makes it a valuable option for patients experiencing these distressing symptoms. Furthermore, its prokinetic action aids in improving gastric emptying, making it beneficial for conditions like gastroparesis, a disorder characterized by delayed stomach emptying.

One of the more specialized uses of Domperidone Maleate is its role in supporting lactation. In many countries, it is prescribed off-label to help increase prolactin levels, which in turn can stimulate breast milk production. This application is particularly relevant for mothers experiencing insufficient milk supply, especially those with premature infants or facing breastfeeding challenges. The exploration of domperidone for lactation support underscores its broader pharmacological impact.

When considering the domperidone maleate dosage for lactation support, it is typically lower than for gastrointestinal indications, often starting at 10 mg three times daily. However, it is crucial to emphasize that this use is off-label and should only be undertaken under the guidance of a qualified healthcare professional. They will assess the individual's needs and monitor for any potential side effects.

Understanding how domperidone works in both scenarios is key. Its dopamine antagonism is the basis for its antiemetic effects, while its influence on prolactin secretion underpins its use in lactation support. Patients and healthcare providers must be aware of potential domperidone maleate drug interactions, particularly with medications that prolong the QT interval or inhibit CYP3A4, to ensure safety.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying high-quality Domperidone Maleate to support these varied therapeutic needs. Our rigorous quality control processes ensure the purity and efficacy of our products, aiding in the development of safe and effective treatments.