Understanding the chemical properties of intermediates is key to their effective utilization in synthesis. NINGBO INNO PHARMCHEM CO.,LTD. provides insights into Bis-Boc-amino-oxyacetic acid (CAS 293302-31-5), a compound whose chemical characteristics make it highly valuable across various research and industrial applications, particularly in organic synthesis.

Bis-Boc-amino-oxyacetic acid, with the molecular formula C12H21NO7 and a molecular weight of 291.3, is a derivative of aminooxyacetic acid where both the amino group and the carboxylic acid group are protected. The tert-butyloxycarbonyl (Boc) groups are particularly significant. These carbamate protecting groups are known for their stability under neutral and basic conditions, making them resistant to many common reagents used in organic synthesis. However, they can be readily cleaved under mild acidic conditions, such as treatment with trifluoroacetic acid (TFA) or HCl in organic solvents. This selective deprotection capability is fundamental to its utility in multi-step syntheses.

The presence of the oxyacetic acid core provides a unique functional handle. The carboxylic acid group, once deprotected or activated, can participate in a variety of reactions, including esterification, amidation, and salt formation. This allows for the covalent attachment of the Bis-Boc-amino-oxyacetic acid moiety to other molecules or solid supports. When used in organic synthesis, this means it can be integrated into complex molecular architectures, serving as a precisely functionalized building block.

The compound typically appears as a white powder, and its solubility characteristics are important for reaction design. While specific solubility data can vary, compounds with Boc protecting groups often exhibit good solubility in common organic solvents like dichloromethane, ethyl acetate, and methanol, facilitating their use in solution-phase synthesis. For applications requiring solid-phase synthesis, it can be immobilized onto resins.

The applications of Bis-Boc-amino-oxyacetic acid are diverse, stemming directly from its chemical properties. In pharmaceutical research, it is a valuable intermediate for constructing novel drug candidates. Its ability to participate in peptide synthesis, as discussed previously, highlights its role in creating biologically active molecules. Beyond peptides, it finds application in the synthesis of other fine chemicals and specialty organic compounds where precise control over functional group reactivity is essential. Its use in bioconjugation, as a linker or a functional tag, also relies on the selective reactivity and stability offered by its protected structure.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with reliable access to high-quality Bis-Boc-amino-oxyacetic acid. Understanding its chemical properties empowers chemists to design more efficient and successful synthetic routes, contributing to advancements in medicine, materials science, and various other chemical industries. The careful synthesis and characterization of this compound ensure its consistent performance in demanding organic synthesis applications.