Proteomics, the large-scale study of proteins, has revolutionized our understanding of biological systems. A key aspect of this field is deciphering the intricate modifications that proteins undergo, which profoundly influence their function and cellular localization. Fmoc-D-Tyr(4-Et)-OH, a specifically designed Fmoc protected tyrosine derivative, is emerging as a valuable tool in this endeavor, enabling researchers to synthesize peptides that mimic or probe these crucial protein modifications.

Fmoc-D-Tyr(4-Et)-OH, with its CAS number 162502-65-0, is characterized by the Fmoc protecting group and an ethoxy modification on the tyrosine side chain. This modification is particularly relevant in the context of tyrosine phosphorylation, a fundamental post-translational modification that plays a critical role in cellular signaling. While Fmoc-D-Tyr(4-Et)-OH itself is not phosphorylated, it serves as an excellent building block for creating synthetic peptides that can be used to study phosphorylation events, develop phosphorylation-detection assays, or explore the interactions of kinases and phosphatases. Researchers often seek to buy Fmoc-D-Tyr(4-Et)-OH for its utility in constructing peptides that mimic or interact with phosphorylated tyrosine residues.

The Fmoc-D-Tyr(4-Et)-OH applications in proteomics are diverse. For instance, it can be incorporated into peptide sequences designed to serve as standards for mass spectrometry-based proteomics. These synthetic peptides, containing the ethoxy modification, can help in identifying and quantifying modified proteins in complex biological samples. Furthermore, researchers investigating protein-tyrosine kinase (PTK) activity may use peptides synthesized with Fmoc-D-Tyr(4-Et)-OH as substrates or inhibitors to study enzyme kinetics and mechanisms. Understanding the optimal Fmoc-D-Tyr(4-Et)-OH price from reputable Fmoc-D-Tyr(4-Et)-OH suppliers ensures that research projects can proceed without interruption.

The precise chemical structure and high purity associated with Fmoc-D-Tyr(4-Et)-OH are paramount for its successful application in proteomics. Impurities can lead to erroneous results, highlighting the importance of sourcing from trusted manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. The ability to reliably buy Fmoc-D-Tyr(4-Et)-OH means that laboratories can consistently obtain the quality reagents needed for sensitive analytical techniques.

Moreover, the ethoxy modification itself can serve as a stable mimic for certain aspects of tyrosine modifications or as a probe to understand the structural requirements for protein-ligand interactions. This makes the Fmoc-O-ethyl-D-tyrosine usage particularly relevant in structural proteomics and chemical biology. By incorporating this residue, scientists can explore how subtle changes in amino acid side chains affect protein behavior and interactions, ultimately contributing to a deeper understanding of cellular processes.

In summary, Fmoc-D-Tyr(4-Et)-OH is an invaluable resource for the proteomics community. Its application in synthesizing modified peptides provides researchers with powerful tools to dissect complex biological pathways, identify protein modifications, and advance our knowledge of cellular signaling. The strategic procurement and utilization of this specialized amino acid derivative are fundamental to pushing the boundaries of proteomic research.