Methyl 2-Aminothiazole-5-Carboxylate, identified by CAS number 6633-61-0, is a chemical compound of significant importance, particularly within the pharmaceutical industry. Its unique structural features and high purity make it an indispensable intermediate in the synthesis of various active pharmaceutical ingredients (APIs), most notably Dasatinib, a targeted therapy for specific forms of leukemia. This article delves into the essential properties, specifications, and diverse applications of this vital organic compound, highlighting why it is a sought-after chemical for manufacturers and researchers alike.

The compound is characterized by its appearance as a brown or yellow powder. Its molecular formula is C5H6N2O2S, with a molecular weight of 158.178 g/mol. These fundamental characteristics are crucial for chemists and process engineers when handling and integrating this substance into complex synthesis chains. The density is reported around 1.4±0.1 g/cm³, and it possesses a relatively high boiling point of approximately 298.7±13.0 °C at 760 mmHg, indicating its stability under typical processing conditions.

When considering its specifications, Methyl 2-Aminothiazole-5-Carboxylate typically boasts an assay of ≥98.0%, ensuring a high level of purity essential for pharmaceutical manufacturing. The melting point, a critical indicator of purity and phase transition, is precisely defined within the range of 184-186°C. These rigorous specifications are met by reliable suppliers, making it easier to secure a consistent supply of this methyl 2-aminothiazole-5-carboxylate. Packaging is usually in 25 kg drums, but flexible options are available to meet specific customer needs, ensuring efficient logistics and storage in cool, ventilated places to maintain its integrity.

The primary application that elevates the importance of Methyl 2-Aminothiazole-5-Carboxylate is its role as a key intermediate in the synthesis of Dasatinib (CAS: 302962-49-8). Dasatinib is a potent tyrosine kinase inhibitor used in cancer treatment, and the precise synthesis of this drug relies heavily on the quality of its precursors. The thiazole ring within the compound's structure provides a versatile scaffold that chemists utilize to construct the complex molecular architecture of Dasatinib. This application underscores the compound's contribution to modern medicine and the demand for high-quality pharmaceutical intermediates.

Furthermore, Methyl 2-Aminothiazole-5-Carboxylate holds broader significance in organic chemistry. The combination of an amino group and an ester functionality on the thiazole ring makes it a reactive and adaptable molecule for a wide array of chemical transformations. This versatility makes it a valuable asset for researchers exploring new synthetic methodologies and developing novel heterocyclic compounds, which are foundational in areas such as medicinal chemistry and materials science. Its availability and predictable behavior in reactions facilitate innovation and discovery.