Exploring the Synthesis and Properties of 1-Benzofuran-5-amine for Chemical Research
At NINGBO INNO PHARMCHEM CO.,LTD., we recognize the foundational importance of key chemical building blocks. One such compound is 1-Benzofuran-5-amine (CAS: 58546-89-7), a molecule of significant interest in organic chemistry due to its versatile reactivity and application potential. This article provides an overview of its synthesis and essential chemical properties, crucial for researchers working in diverse scientific fields.
The synthesis of 1-Benzofuran-5-amine often involves the reduction of its nitro precursor. Detailed synthetic protocols, such as those involving the reduction of 5-nitrobenzofuran using iron powder and hydrochloric acid, or other established chemical reduction methods, are critical for obtaining this compound with high purity and yield. Understanding these 1-benzofuran-5-amine synthesis routes is fundamental for chemists aiming to replicate or optimize its production for various research purposes. The efficiency and scalability of these methods directly impact the availability of this crucial intermediate.
The chemical properties of 1-Benzofuran-5-amine, including its boiling point of approximately 259.8 °C and a density of 1.225 g/cm³, are vital data points for chemists. These parameters inform decisions regarding reaction conditions, purification techniques, and safe handling. As a member of the benzofuran family, it possesses a unique fused ring system that contributes to its reactivity and potential for derivatization. Researchers frequently leverage these characteristics in exploring new benzofuran derivatives synthesis.
The utility of 1-Benzofuran-5-amine extends across various sectors, prominently within pharmaceutical intermediates benzofuran applications. Its structure serves as an excellent starting point for designing molecules with specific biological activities, making it indispensable in drug discovery. The ongoing research into heterocyclic compounds synthesis continually highlights compounds like 1-Benzofuran-5-amine for their ability to form complex and biologically relevant structures. By understanding its properties and synthesis, researchers can more effectively utilize this compound as a key component in their chemical endeavors, driving innovation in the field of chemistry.
Perspectives & Insights
Core Pioneer 24
“The synthesis of 1-Benzofuran-5-amine often involves the reduction of its nitro precursor.”
Silicon Explorer X
“Detailed synthetic protocols, such as those involving the reduction of 5-nitrobenzofuran using iron powder and hydrochloric acid, or other established chemical reduction methods, are critical for obtaining this compound with high purity and yield.”
Quantum Catalyst AI
“Understanding these 1-benzofuran-5-amine synthesis routes is fundamental for chemists aiming to replicate or optimize its production for various research purposes.”