Exploring the Chemical Properties and Reactivity of 3-Iodobenzoic Acid
3-Iodobenzoic Acid, identified by CAS number 618-51-9, is a fascinating organic compound whose utility stems directly from its distinct chemical properties and reactivity. NINGBO INNO PHARMCHEM CO.,LTD., a reputable manufacturer in China, supplies this compound, enabling chemists to explore its versatile applications in organic synthesis.
The molecule features two key functional groups: a carboxylic acid (-COOH) and an iodine atom (-I) attached to a benzene ring in a meta (3-) position. The carboxylic acid group imparts acidic properties and allows for typical reactions such as esterification, amidation, and salt formation. This makes it amenable to various derivatization processes, which are common in the synthesis of complex molecules, including pharmaceutical intermediates.
The iodine atom is the other critical functional group that dictates much of 3-iodobenzoic acid's reactivity. Iodine is a relatively good leaving group and is highly susceptible to nucleophilic attack and participation in transition metal-catalyzed cross-coupling reactions. This is why understanding the 3-iodobenzoic acid chemical properties is so vital. Reactions like Suzuki, Heck, Sonogashira, and Ullmann couplings readily occur at the carbon-iodine bond, allowing for the introduction of a wide array of substituents onto the aromatic ring. These reactions are foundational in building complex organic scaffolds found in APIs and other specialty chemicals.
The meta-substitution pattern also influences the electronic distribution within the benzene ring, affecting the reactivity of both the carboxylic acid and the iodine atom. This specific arrangement is often sought after for particular synthetic targets. As a pharmaceutical intermediate 3-iodobenzoic acid, its precise structure is key to building the specific molecular architectures required for biological activity.
As a supplier, NINGBO INNO PHARMCHEM CO.,LTD. ensures that the high purity iodobenzoic acid we provide exhibits predictable and reliable reactivity, which is crucial for successful research and manufacturing. Whether you are looking to buy 3-iodobenzoic acid CAS 618-51-9 for academic research or industrial production, understanding its chemical behavior is the first step towards unlocking its full potential.
Perspectives & Insights
Logic Thinker AI
“Iodine is a relatively good leaving group and is highly susceptible to nucleophilic attack and participation in transition metal-catalyzed cross-coupling reactions.”
Molecule Spark 2025
“Reactions like Suzuki, Heck, Sonogashira, and Ullmann couplings readily occur at the carbon-iodine bond, allowing for the introduction of a wide array of substituents onto the aromatic ring.”
Alpha Pioneer 01
“These reactions are foundational in building complex organic scaffolds found in APIs and other specialty chemicals.”