In the realm of pharmaceutical chemistry, specific compounds serve as linchpins in the synthesis of complex medicinal agents. 4-(2,4-Difluorobenzoyl)piperidine hydrochloride, identified by its CAS number 106266-04-0, is one such compound. This off-white to light yellow powder is highly regarded for its role as a critical intermediate, particularly in the production of antipsychotic drugs. This article delves into its chemical composition, physical properties, and significant applications, highlighting why it is a sought-after material for pharmaceutical manufacturers.

The chemical identity of 4-(2,4-Difluorobenzoyl)piperidine hydrochloride is defined by its molecular formula, C12H14ClF2NO, and a molecular weight of approximately 261.695 g/mol. Its physical characteristics include a density of around 1.02 g/cm³, a boiling point of 122°C at 9 mmHg, and a melting point that decomposes between 203°C and 206°C. Crucially for its application in pharmaceutical synthesis, it typically exhibits an assay between 98.5% and 101.5%, indicating a high level of purity. When dissolved, it forms a clear and colorless solution, further attesting to its quality. These attributes make it an ideal chemical synthesis building block.

The primary application driving the demand for 4-(2,4-Difluorobenzoyl)piperidine hydrochloride is its indispensable role as an intermediate in the synthesis of Risperidone. Risperidone is a widely prescribed antipsychotic medication used to treat conditions such as schizophrenia, bipolar disorder, and irritability associated with autism. The successful synthesis of Risperidone hinges on the precise molecular structure and reactivity of its intermediates, including this particular fluorinated compound. The rigorous nature of risperidone intermediate synthesis demands intermediates that meet exacting purity standards, which is where a reliable 4-(2,4-Difluorobenzoyl)piperidine hydrochloride supplier becomes essential.

Beyond this primary use, the compound's chemical structure, featuring a piperidine ring and difluorobenzoyl group, lends itself to broader applications within chemical synthesis. It can be utilized as a versatile building block for creating other novel chemical entities with potential pharmaceutical activity. This makes it an attractive material for research and development efforts focused on discovering new therapeutics. Pharmaceutical companies often seek out specialized expertise from a 4-(2,4-Difluorobenzoyl)piperidine hydrochloride manufacturer in China, known for their capabilities in producing high-quality intermediates.

Proper storage and handling are also critical to maintain the integrity of 4-(2,4-Difluorobenzoyl)piperidine hydrochloride. Storing it in a cool, well-ventilated area, often packaged in 25 kg drums, is recommended. The consistent quality and purity of this intermediate are paramount for pharmaceutical manufacturers, ensuring the efficiency and reliability of their production processes and ultimately contributing to the availability of essential medications worldwide.