4-Bromophenylacetic acid (CAS 1878-68-8) is a compound of significant interest in the field of organic chemistry, primarily due to its utility as a versatile intermediate. Understanding its synthesis and chemical properties is fundamental to leveraging its full potential in various applications, from pharmaceutical development to advanced material science.

The synthesis of 4-Bromophenylacetic acid typically involves several established organic chemistry routes. One common approach starts with readily available precursors, often involving bromination of phenylacetic acid derivatives or functionalization of brominated benzene compounds. For example, the esterification of 4-bromobenzaldehyde followed by a series of reactions, or direct bromination of phenylacetic acid under controlled conditions, can yield the desired product. The efficiency and scalability of these synthetic pathways are crucial for manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. to meet market demands, ensuring a stable supply of 4-Bromophenylacetic acid.

Chemically, 4-Bromophenylacetic acid exhibits characteristics typical of both aromatic bromides and carboxylic acids. Its melting point, generally reported between 114-117°C, classifies it as a solid at room temperature, and its appearance is often described as an almost white to light yellow-beige crystalline powder. The presence of the bromine atom on the aromatic ring makes it susceptible to various nucleophilic substitution reactions and palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. These reactions are cornerstone methodologies for building complex carbon frameworks.

Furthermore, the carboxylic acid group (-COOH) imparts acidity, with a reported pKa value around 4.188, allowing it to participate in acid-base reactions, esterification, and amide formation. This dual functionality makes 4-Bromophenylacetic acid an exceptionally valuable building block. Researchers can selectively modify either the carboxylic acid group or the aromatic bromide, opening up a wide array of synthetic possibilities. The ability to control these reactions precisely is key, making the purchase of 4-Bromophenylacetic acid from a reliable manufacturer in China, such as NINGBO INNO PHARMCHEM CO.,LTD., essential for consistent results.

The solubility profile of 4-Bromophenylacetic acid is also noteworthy. It shows solubility in organic solvents like ethanol and chloroform, which are commonly used in synthesis. This solubility facilitates its use in solution-phase reactions. For those looking to buy 4-Bromophenylacetic acid for industrial purposes, understanding these properties ensures the correct choice of reaction conditions and solvents, ultimately optimizing the synthesis process. NINGBO INNO PHARMCHEM CO.,LTD. offers this compound with the assurance of quality, supporting critical research and development efforts.