In the complex landscape of drug discovery, specialized chemical building blocks are indispensable for synthesizing novel therapeutic agents. Fmoc-4-Nitro-L-Phenylalanine, also known as Fmoc-Phe(4-NO2)-OH, is a prime example of such a versatile compound. Its unique chemical features make it a valuable asset in medicinal chemistry, enabling the creation of molecules with targeted biological activities, particularly in the area of inflammatory disease research.

The compound's fundamental identity is established by its Chemical Name: N-Fmoc-4-Nitro-L-Phenylalanine, and its CAS No.: 95753-55-2. With a precisely defined Molecular Formula of C24H20N2O6 and a Molecular Weight of approximately 432.43 g/mol, it provides the necessary specificity for medicinal chemists. It is typically supplied as a white to off-white powder with a purity exceeding 98% (HPLC), ensuring its reliability in sensitive synthetic procedures. Proper storage conditions, such as maintaining it at 2-8°C, are essential for preserving its chemical integrity.

The primary utility of Fmoc-4-Nitro-L-Phenylalanine in medicinal chemistry lies in its role as a modified amino acid for peptide synthesis. The presence of the nitro group on the phenylalanine side chain offers distinct advantages. It can be used to introduce a nitrophenylalanine residue into peptides, which can then function as an IR probe for structural analysis or as a quencher in FRET assays, vital tools for understanding molecular interactions. Furthermore, this compound is a critical intermediate in the synthesis of squaric acid derivatives designed as VLA-4 integrin antagonists. The targeting of VLA-4 integrins is a significant strategy for developing treatments for conditions such as multiple sclerosis, inflammatory bowel disease, and asthma, positioning Fmoc-4-Nitro-L-Phenylalanine at the forefront of this research.

The compound's application extends to the synthesis of analogs of natural products like kahalalide F, a cyclic peptide with cytotoxic properties. This demonstrates its versatility in constructing complex organic structures with potential therapeutic benefits. The availability of high-quality Fmoc-4-Nitro-L-Phenylalanine from reputable suppliers such as NINGBO INNO PHARMCHEM CO.,LTD. is crucial for accelerating drug discovery programs. By providing access to these advanced amino acid derivatives, researchers can efficiently explore new chemical spaces and develop innovative therapies.

In summary, Fmoc-4-Nitro-L-Phenylalanine is more than just a chemical reagent; it is a foundational element in the development of novel therapeutics. Its application in creating specific peptide structures and as a key intermediate for compounds targeting crucial biological pathways like integrin signaling underscores its importance in modern medicinal chemistry and drug development.