Fmoc-Glycine, cataloged under CAS number 29022-11-5, is a fundamental compound in modern organic and biochemical research, particularly valued for its role in peptide synthesis. Its identity as an N-protected amino acid derivative, specifically glycine with the 9-fluorenylmethoxycarbonyl (Fmoc) group, makes it a critical reagent for scientists engaged in creating complex peptides and related molecules. The consistent demand for high-purity Fmoc-Glycine highlights the importance of understanding its properties, synthesis, and applications. Reliable suppliers, such as NINGBO INNO PHARMCHEM CO.,LTD., play a crucial role in ensuring that researchers have access to this essential chemical tool.

The core advantage of Fmoc-Glycine lies in the Fmoc protecting group, which shields the amino terminus of glycine. This protection is essential for controlled, sequential coupling of amino acids during solid-phase peptide synthesis (SPPS). Glycine, being the simplest amino acid without a chiral center, is a frequent component in many peptide sequences, and its Fmoc-protected form ensures efficient and precise incorporation. Fmoc-Glycine typically appears as a white powder, with its purity being a paramount consideration. Manufacturers often specify a purity of ≥99% by High-Performance Liquid Chromatography (HPLC). This high level of purity is vital to prevent side reactions, ensure the structural integrity of synthesized peptides, and guarantee the reliability of experimental outcomes. Understanding these Fmoc-Glycine purity standards is key for researchers selecting their materials.

The synthesis of Fmoc-Glycine generally involves reacting glycine with Fmoc-Cl (9-fluorenylmethoxycarbonyl chloride) in the presence of a suitable base, such as triethylamine or diisopropylethylamine. The reaction conditions are carefully controlled to optimize yield and purity. Post-synthesis purification, often through recrystallization or chromatography, is critical to remove any residual reactants or byproducts. The efficiency and reliability of these manufacturing processes are supported by chemical companies, especially those in China, which have become prominent suppliers. NINGBO INNO PHARMCHEM CO.,LTD., for instance, is a recognized manufacturer and supplier known for its commitment to quality and its capacity to produce Fmoc-Glycine in quantities required for both research and industrial applications. When researchers look to buy Fmoc-Glycine, they often seek these specialized suppliers for their quality assurance and consistent product availability.

The applications of Fmoc-Glycine are diverse, extending to pharmaceutical research, drug discovery, and various biochemical studies. In pharmaceutical development, it serves as a key intermediate in the synthesis of peptide-based drugs, which are increasingly important for treating conditions like cancer, diabetes, and autoimmune diseases. Its use in creating peptides for diagnostic assays and as tools for studying protein-ligand interactions further emphasizes its versatility. For those in chemical research, having access to a consistent supply of high-purity Fmoc-Glycine is fundamental to progress. Partnering with established Fmoc-Glycine suppliers ensures that this critical reagent is available when needed, facilitating uninterrupted research and development cycles.

In essence, Fmoc-Glycine (CAS 29022-11-5) is more than just a chemical compound; it is an enabler of scientific discovery. Its precise chemical properties, combined with meticulous manufacturing and stringent purity controls, make it an invaluable asset. NINGBO INNO PHARMCHEM CO.,LTD. contributes significantly to the scientific community by providing this essential component, underpinning advances in peptide science and medicinal chemistry.