The choice of solvent system for pharmaceutical coating significantly impacts both the efficiency of the process and its environmental footprint. At NINGBO INNO PHARMCHEM, we recognize the growing importance of sustainable manufacturing practices. This is why we place a strong emphasis on utilizing Hypromellose Acetate Succinate (HPMCAS) in aqueous coating systems whenever possible, offering a greener alternative for achieving effective enteric protection and other drug delivery functionalities.

Traditionally, many enteric coatings have relied on organic solvents. While effective, these solvents often pose risks related to flammability, toxicity, and environmental disposal. HPMCAS, however, offers a remarkable advantage: its suitability for aqueous coating formulations. By carefully preparing a suspension of fine HPMCAS powder, typically with a plasticizer like triethyl citrate and a wetting agent, we can achieve high-quality coatings without the use of organic solvents. This not only enhances safety but also reduces production costs and regulatory burdens associated with solvent handling and recovery.

The efficacy of aqueous HPMCAS coating is well-documented. The fine particle size grades of HPMCAS are specifically designed for stable dispersion in water, forming a uniform coating solution. This allows for consistent application onto tablets, capsules, or pellets, ensuring reliable enteric protection. The pH-dependent dissolution properties of HPMCAS remain intact, guaranteeing targeted drug release in the small intestine. NINGBO INNO PHARMCHEM works closely with clients to identify the optimal HPMCAS grade and formulation for their specific product needs, whether they choose to buy in bulk or require customized solutions.

While aqueous systems are often preferred, solvent-based coating using HPMCAS is still a viable option for certain applications or when specific processing parameters are required. The choice depends on factors such as the API's stability in aqueous media, the desired drying rate, and available manufacturing infrastructure. NINGBO INNO PHARMCHEM is equipped to support both approaches, providing expertise in the formulation and application of HPMCAS for optimal drug delivery outcomes.

The ability to use HPMCAS in both aqueous and solvent systems underscores its versatility. For pharmaceutical companies looking to buy HPMCAS, understanding these different application methods is key to maximizing its benefits. NINGBO INNO PHARMCHEM is committed to advancing sustainable pharmaceutical manufacturing by promoting the use of aqueous-based HPMCAS coatings. Our technical team is available to discuss your formulation challenges and provide tailored solutions, helping you to achieve superior drug product performance with an environmentally conscious approach.