In the pharmaceutical industry, the quality and purity of active pharmaceutical ingredients (APIs) and their intermediates are non-negotiable. Leucovorin Calcium (CAS 1492-18-8) stands out as a critical pharmaceutical intermediate, essential for its role in oncology and hematology. Known for its use as an antidote to methotrexate toxicity and as a potentiator for other chemotherapeutic agents like 5-fluorouracil, its reliable sourcing is paramount for patient safety and treatment efficacy. NINGBO INNO PHARMCHEM CO.,LTD. is a premier supplier, offering high-purity Leucovorin Calcium that meets rigorous global standards.

Leucovorin Calcium, chemically identified as Calcium 5-formyltetrahydrofolate, is the biologically active form of folic acid. Its primary therapeutic applications stem from its ability to counteract the adverse effects of folate antagonists, most notably methotrexate. In high-dose methotrexate therapy, which is common in the treatment of various cancers, methotrexate's inhibition of dihydrofolate reductase can lead to severe toxicity in healthy cells. Leucovorin Calcium acts as a rescue agent by providing an alternative source of reduced folate, thereby protecting these vital cells. This 'leucovorin rescue' protocol is a cornerstone of safe and effective methotrexate treatment. Access to reliable leucovorin calcium 1492-18-8 is vital for these protocols.

Another significant application is in combination chemotherapy for advanced colorectal cancer, where it is administered with 5-fluorouracil (5-FU). This synergistic combination enhances the antitumor activity of 5-FU by stabilizing its binding to thymidylate synthase, leading to more effective DNA synthesis inhibition in cancer cells. This application underscores the compound's importance in improving patient outcomes in challenging cancer treatments.

The specifications for pharmaceutical-grade Leucovorin Calcium are exacting. Manufacturers and formulators rely on products with high purity, typically a minimum assay of 99.5%, and compliance with established pharmacopeial standards such as USP (United States Pharmacopeia), BP (British Pharmacopoeia), EP (European Pharmacopoeia), and FCC (Food Chemicals Codex). NINGBO INNO PHARMCHEM CO.,LTD. is committed to meeting these stringent requirements, ensuring that every batch of our Leucovorin Calcium is of the highest quality. Our clients can confidently buy leucovorin calcium knowing they are receiving a product that adheres to these critical standards.

For pharmaceutical companies and researchers, sourcing raw materials requires a partner that prioritizes quality, consistency, and reliability. NINGBO INNO PHARMCHEM CO.,LTD. offers a streamlined procurement process, including easy online access for product inquiries and competitive leucovorin calcium price information. We understand the importance of a robust supply chain and are dedicated to serving the global pharmaceutical market with excellence.

In summary, Leucovorin Calcium (CAS 1492-18-8) is an indispensable pharmaceutical intermediate with critical roles in supportive cancer care and direct therapeutic applications. NINGBO INNO PHARMCHEM CO.,LTD. is your trusted partner for sourcing high-purity Leucovorin Calcium, meeting the demanding specifications required for pharmaceutical formulations and ensuring the highest standards of patient care.