4-Chloro-4'-hydroxybenzophenone, identified by its CAS number 42019-78-3, is a compound of significant importance in the chemical industry, particularly as a pharmaceutical intermediate for Fenofibrate. A thorough understanding of its properties and synthesis is crucial for both manufacturers and users. This crystalline powder, typically white to light brown, with an assay of 98.0% or higher, is characterized by its specific physical and chemical attributes that dictate its handling, storage, and application.

The physical properties of 4-Chloro-4'-hydroxybenzophenone include a molecular formula of C13H9ClO2 and a molecular weight of 232.662 g/mol. Its density is around 1.3±0.1 g/cm³, and it possesses a melting point in the range of 177-181 °C. The boiling point is notably high, approximately 404.0±30.0 °C at 760 mmHg, which suggests good thermal stability. The flash point of 198.1±24.6 °C further indicates its relative safety in terms of flammability. These parameters are vital for chemical engineers designing reaction and purification processes, as well as for logistics and storage planning.

The synthesis of 4-Chloro-4'-hydroxybenzophenone often involves established chemical reactions. Methods such as the Friedel-Crafts acylation or Fries rearrangement are commonly employed, utilizing precursors like phenol and p-chlorobenzoyl chloride. The efficiency and yield of these synthesis routes are continuous areas of focus for chemical manufacturers seeking to optimize production. Factors such as catalyst selection, reaction temperature, time, and solvent choice all play a significant role in achieving high purity and good yields. The challenge lies in managing by-products and ensuring effective purification to meet the stringent purity requirements for its use as a pharmaceutical intermediate.

When handling and storing 4-Chloro-4'-hydroxybenzophenone, adherence to safety guidelines is essential. It is typically packaged in drums, often 25 kg, but can be customized. Storage in a cool, well-ventilated area is recommended to maintain its integrity. For businesses requiring this crucial intermediate, partnering with a reputable supplier like NINGBO INNO PHARMCHEM CO.,LTD. guarantees access to a product that meets high-quality standards. Our expertise in chemical synthesis and commitment to quality assurance ensure that our clients receive a reliable product, essential for their manufacturing needs.