The world of organic synthesis is built upon a foundation of versatile and reactive chemical intermediates. Among these, 3-((tert-butyldimethylsilyl)oxy)propyl 4-nitrobenzenesulfonate stands out due to its specific functionalities, making it an invaluable component in the synthesis of pharmaceuticals like Silodosin. This article explores the critical properties of this compound, often referred to by its CAS number 220299-14-9, and its significance in advanced chemical processes.

The physical and chemical properties of 3-((tert-butyldimethylsilyl)oxy)propyl 4-nitrobenzenesulfonate are key to its application. Typically appearing as a White Powder, it possesses a molecular formula of C15H25NO6SSi and a molecular weight of 375.513. Its density is noted around 1.2 g/cm³, with a high boiling point of approximately 451.5 °C at 760 mmHg and a flash point of around 226.9 °C. These characteristics are important for handling and processing in industrial settings, ensuring stability and safety during manufacturing stages.

As a Silodosin intermediate, the compound’s reactivity is meticulously managed. The tert-butyldimethylsilyl (TBDMS) ether moiety offers robust protection for the alcohol group, readily cleaved under specific conditions when needed. Concurrently, the 4-nitrobenzenesulfonate ester group serves as an excellent leaving group, a characteristic exploited in nucleophilic substitution reactions critical for building the Silodosin molecule. The detailed understanding of these chemical properties of 3-((tert-butyldimethylsilyl)oxy)propyl 4-nitrobenzenesulfonate allows chemists to design efficient reaction sequences.

The utility of this intermediate extends beyond just its role in Silodosin production. It can serve as a valuable reagent in various organic synthesis transformations, offering a protected alcohol and a reactive sulfonate ester. This dual functionality makes it a versatile tool for synthetic chemists developing complex organic molecules. The reliability of CAS 220299-14-9 chemical properties ensures reproducibility in synthetic protocols.

For manufacturers and researchers, securing a consistent supply of high-quality 3-((tert-butyldimethylsilyl)oxy)propyl 4-nitrobenzenesulfonate is essential for the seamless production of pharmaceuticals. NINGBO INNO PHARMCHEM CO.,LTD. plays a vital role in this by providing this critical compound, thereby supporting advancements in both chemical synthesis and pharmaceutical therapy. The focus on maintaining purity and well-defined chemical structure of 3-[tert-butyl(dimethyl)silyl]oxypropyl 4-nitrobenzenesulfonate is a testament to its importance.

In summary, the specific properties of 3-((tert-butyldimethylsilyl)oxy)propyl 4-nitrobenzenesulfonate are fundamental to its role as a crucial intermediate. Its controlled reactivity and protective groups are expertly utilized in Silodosin synthesis pathways, underscoring its significance in the chemical industry.