For pharmaceutical formulators, selecting the correct form of Lidocaine is crucial for achieving desired therapeutic outcomes. NINGBO INNO PHARMCHEM CO.,LTD. clarifies the distinctions between Lidocaine Base powder (CAS 137-58-6) and Lidocaine Hydrochloride, two essential forms of this widely used compound.

Lidocaine Base, a white crystalline powder, is characterized by its low solubility in water but good solubility in organic solvents like ethanol. Its chemical structure is C14H22N2O, with a molecular weight of approximately 234.34 g/mol. Due to its non-ionized nature, Lidocaine Base is generally preferred for formulations where it needs to penetrate lipid barriers, such as in topical applications intended for absorption through the skin before a pain stimulus is applied. When seeking lidocaine powder for sale for such applications, formulators often opt for the base form.

Lidocaine Hydrochloride, on the other hand, is the salt form, typically appearing as a white crystalline powder with the chemical formula C14H23ClN2O·H2O. It is highly soluble in water and has a pKa of around 7.8. This water solubility makes Lidocaine Hydrochloride ideal for aqueous formulations, such as injectable solutions, gels, and viscous liquids used for mucous membranes or when the patient is already experiencing pain, as the ionized form binds more effectively to sodium channels in activated neurons. When searching for lidocaine hydrochloride powder, formulators look for high purity and compliance with relevant pharmacopoeial standards.

The choice between Lidocaine Base and Lidocaine Hydrochloride often depends on the intended route of administration, the pH of the formulation vehicle, and the desired onset and duration of action. Understanding the lidocaine synthesis and the resulting chemical properties is key to making an informed decision. For formulators, reliable access to both forms from trusted lidocaine powder suppliers is essential.

NINGBO INNO PHARMCHEM CO.,LTD. supplies both high-purity Lidocaine Base powder and Lidocaine Hydrochloride to meet diverse pharmaceutical formulation needs. By offering these critical intermediates, we support innovation in drug development and ensure that formulators have the building blocks necessary for creating effective anesthetic and antiarrhythmic treatments. Choosing the right form of Lidocaine is a fundamental step in developing safe and efficient medications.