N-Boc-4-piperidone: A Crucial Intermediate for Advancing Pharmaceutical Treatments
The pharmaceutical industry is constantly seeking efficient and reliable methods to synthesize novel and existing drug compounds. Central to this endeavor is the strategic use of high-quality chemical intermediates. N-(tert-Butoxycarbonyl)-4-piperidone, also known as N-Boc-4-piperidone or 1-Boc-4-Piperidone, with CAS number 79099-07-3, has emerged as a key player in this domain. This versatile compound's unique chemical properties and its role as a precursor in the synthesis of a wide array of pharmaceuticals make it indispensable for advancing global health outcomes. From its physical characteristics to its broad therapeutic applications, N-Boc-4-piperidone is a compound of significant importance.
The compound typically presents as a white to light yellow powder, a testament to its high purity, often exceeding 99.0%. This level of purity is essential for pharmaceutical synthesis, where even minute impurities can compromise the efficacy and safety of the final drug product. N-Boc-4-piperidone possesses a melting point in the range of 73-77°C and a boiling point of approximately 289.8±33.0 °C at 760 mmHg, indicative of its stability under standard processing conditions. Its density, around 1.1 g/cm³, along with a low loss on drying (≤1.0%), further emphasizes its suitability for precise chemical operations. The presence of the tert-butoxycarbonyl (Boc) group is particularly noteworthy. As a widely used protecting group in organic chemistry, the Boc moiety shields the nitrogen atom of the piperidone ring, allowing for selective modifications at other positions of the molecule. This controlled reactivity is a cornerstone of efficient drug synthesis, enabling chemists to build complex molecular structures step-by-step.
The impact of N-Boc-4-piperidone on pharmaceutical treatments is profound. It serves as a critical intermediate in the synthesis of several classes of drugs. For instance, it is used in the preparation of Angiotensin-converting enzyme (ACE) inhibitors, essential medications for managing hypertension and heart failure. Its contribution to the development of anti-AIDS protease inhibitors, such as Indinavir, further highlights its significance in combating life-threatening viral infections. The versatility of this compound extends to its role in synthesizing drugs for degenerative diseases, certain cancers, and conditions caused by viral, fungal, and bacterial infections. The ability to buy N-Boc-4-piperidone from reliable sources, often N-Boc-4-piperidone manufacturers in China, ensures that these crucial medications can be produced consistently and affordably worldwide.
Beyond its direct role in API synthesis, N-Boc-4-piperidone is a valuable tool in broader medicinal chemistry research. It enables the exploration of new chemical entities and the optimization of existing drug candidates. The ease with which the Boc group can be removed under acidic conditions after the desired synthetic transformations have been completed makes it an exceptionally practical intermediate. This characteristic streamlines synthetic pathways, reduces the number of steps required, and ultimately lowers production costs, making essential treatments more accessible.
In conclusion, N-(tert-Butoxycarbonyl)-4-piperidone is a vital component in the pharmaceutical synthesis landscape. Its high purity, protective group functionality, and broad applicability in creating critical drugs underscore its importance. As research continues to push the boundaries of medical science, intermediates like N-Boc-4-piperidone will remain instrumental in developing the next generation of life-saving therapies.
Perspectives & Insights
Future Origin 2025
“The compound typically presents as a white to light yellow powder, a testament to its high purity, often exceeding 99.”
Core Analyst 01
“This level of purity is essential for pharmaceutical synthesis, where even minute impurities can compromise the efficacy and safety of the final drug product.”
Silicon Seeker One
“N-Boc-4-piperidone possesses a melting point in the range of 73-77°C and a boiling point of approximately 289.”