The compound 8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione, bearing the CAS number 22316-55-8, is widely recognized in scientific circles as N-Desmethylclobazam. This substance holds considerable importance as a primary active metabolite of clobazam, a benzodiazepine medication primarily used to treat epilepsy. Its presence and activity in the body make it a focal point in pharmaceutical research and a key analyte in forensic toxicology.

In the realm of pharmaceuticals, understanding drug metabolism is crucial for optimizing therapeutic efficacy and minimizing adverse effects. N-Desmethylclobazam is formed in the liver through the action of cytochrome P450 enzymes, specifically CYP3A4. Its pharmacological activity, which involves positively modulating GABAA receptors, contributes significantly to the overall therapeutic profile of clobazam. Researchers often seek to buy high-purity N-Desmethylclobazam to study its pharmacokinetic properties, its contribution to the parent drug's effects, and to develop more targeted therapies. The availability of this compound for purchase from specialized suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is essential for these studies.

In forensic science, the accurate detection and quantification of drug metabolites are vital for establishing drug use and assessing impairment. N-Desmethylclobazam is frequently monitored in biological samples such as urine, serum, and plasma, as it can persist longer than the parent drug clobazam. Forensic toxicologists rely on high-quality reference standards of N-Desmethylclobazam to calibrate their analytical instruments, such as GC-MS and LC-MS, ensuring the precision and reliability of their results. The competitive price and consistent quality offered by suppliers like NINGBO INNO PHARMCHEM CO.,LTD. are therefore highly valued in forensic laboratories.

The synthesis of 8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione involves intricate chemical processes designed to achieve the required purity for its specialized applications. Companies dedicated to fine chemical production, such as NINGBO INNO PHARMCHEM CO.,LTD., invest heavily in sophisticated synthesis and purification techniques. This ensures that the compound supplied meets the stringent requirements for both pharmaceutical research and forensic analysis. The accessibility of this chemical for purchase supports ongoing investigations into drug effects and detection methods.

In summary, N-Desmethylclobazam (CAS 22316-55-8) is a compound of significant scientific value. Its role as a clobazam metabolite, its GABAA receptor modulatory activity, and its importance as an analytical standard underscore its relevance in both pharmaceutical development and forensic toxicology. Reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. are instrumental in providing the high-quality chemical needed to advance these critical fields.