NINGBO INNO PHARMCHEM CO.,LTD. provides high-grade Domperidone Maleate (CAS: 99497-03-7), a key compound in pharmaceutical applications. This article focuses on the intricate pharmacology and safety profile of Domperidone Maleate, offering valuable insights for professionals in the pharmaceutical industry and healthcare sector.

Domperidone Maleate's therapeutic efficacy is rooted in its mechanism of action as a selective peripheral dopamine D2 and D3 receptor antagonist. Unlike many other dopamine antagonists, it exhibits limited penetration across the blood-brain barrier. This characteristic is instrumental in its therapeutic use for managing nausea and vomiting, as it targets the chemoreceptor trigger zone (CTZ) without causing significant central nervous system side effects like extrapyramidal symptoms. This precise targeting is fundamental to understanding how domperidone works effectively.

The drug's prokinetic activity is another significant aspect of its pharmacology. It enhances gastrointestinal motility by increasing the release of acetylcholine, thereby accelerating gastric emptying. This makes Domperidone Maleate a valuable treatment for conditions such as gastroparesis. Proper adherence to the recommended domperidone maleate dosage is crucial for achieving the desired therapeutic effect in these cases.

The safety profile of Domperidone Maleate requires careful consideration. While generally well-tolerated, potential side effects can include dry mouth, abdominal cramps, and diarrhea. More serious, though rare, adverse effects are associated with cardiac issues, such as QT interval prolongation and arrhythmias. This risk is amplified when Domperidone Maleate is co-administered with certain medications. Understanding domperidone maleate drug interactions is therefore critically important. For instance, potent CYP3A4 inhibitors and other QT-prolonging drugs can elevate domperidone levels, increasing the potential for cardiac adverse events.

Beyond its primary indications, Domperidone Maleate is also used off-label to stimulate lactation. This application leverages its influence on prolactin secretion, demonstrating its diverse pharmacological capabilities. Patients considering domperidone for lactation support must consult with healthcare professionals to ensure its safe and appropriate use.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality Domperidone Maleate, adhering to strict manufacturing standards. Our commitment ensures that researchers and manufacturers have access to a reliable ingredient for developing safe and effective pharmaceutical products.