NINGBO INNO PHARMCHEM CO.,LTD. is a trusted supplier of Domperidone Maleate (CAS: 99497-03-7), a vital component in modern pharmacotherapy. This article provides essential guidance for healthcare professionals on the practical aspects of prescribing Domperidone Maleate, focusing on dosage, drug interactions, and contraindications.

Understanding how domperidone works is fundamental to its effective prescription. As a peripheral dopamine antagonist, it targets the chemoreceptor trigger zone, alleviating nausea and vomiting with minimal central effects. Its prokinetic action also aids in improving gastric emptying, making it beneficial for conditions like gastroparesis. For these indications, the typical domperidone maleate dosage for adults is 10-20 mg, administered three to four times daily, preferably before meals. Ensuring patients understand and adhere to the correct domperidone maleate dosage is crucial for therapeutic success.

A critical aspect of prescribing Domperidone Maleate involves navigating domperidone maleate drug interactions. It is imperative to review all concomitant medications. Drugs that inhibit CYP3A4 enzymes (e.g., ketoconazole, erythromycin, certain protease inhibitors) can significantly increase plasma concentrations of domperidone, leading to an elevated risk of cardiac arrhythmias. Similarly, caution is advised with other medications known to prolong the QT interval. Patients should be advised to report all medications, including over-the-counter drugs and herbal supplements, to their healthcare provider.

Identifying contraindications is equally important. Domperidone Maleate is contraindicated in patients with known hypersensitivity, prolactinoma, severe hepatic impairment, or pre-existing cardiac conditions that could be exacerbated by QT prolongation. Patients with gastrointestinal bleeding, obstruction, or perforation should also not receive the medication. Special consideration is needed for elderly patients, who may have an increased risk of side effects.

While not a primary indication, the use of Domperidone Maleate for domperidone for lactation support is also noted. In such cases, the dosage and duration of treatment must be carefully managed by a specialist, weighing the potential benefits against the risks. NINGBO INNO PHARMCHEM CO.,LTD. ensures the quality of our Domperidone Maleate, supporting healthcare providers in delivering safe and effective treatments.