The Role of Fmoc-Lys(ivDde)-OH in Site-Specific Peptide Modification and Bioconjugation
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to advancing the field of peptide chemistry through the provision of high-quality reagents. Among these, Fmoc-Lys(ivDde)-OH is a standout product, playing a pivotal role in site-specific peptide modification and bioconjugation. Its unique chemical properties allow researchers to precisely tailor peptides for a wide range of sophisticated applications, from drug delivery systems to diagnostic tools.
The core utility of Fmoc-Lys(ivDde)-OH lies in its dual protection strategy. The standard Fmoc group protects the alpha-amino terminus, essential for routine peptide chain elongation in Fmoc SPPS. The critical feature, however, is the ivDde protecting group on the epsilon-amino side chain of lysine. This group is designed for selective removal under mild conditions, typically using hydrazine or hydroxylamine. This selectivity is crucial because it enables chemists to deprotect the lysine side chain at a specific stage of synthesis, without affecting other protecting groups like Boc or t-butyl, which are often sensitive to acidic cleavage.
This capability directly translates to enhanced site-specific peptide modification. By selectively exposing the epsilon-amino group of lysine, researchers can conjugate various molecules to the peptide. This includes the attachment of fluorescent dyes for tracking or imaging purposes, biotin for affinity purification or detection, or polyethylene glycol (PEG) for improving pharmacokinetic properties, solubility, and reducing immunogenicity of therapeutic peptides. The ability to achieve such precise conjugation is a cornerstone of effective bioconjugation strategies.
Moreover, Fmoc-Lys(ivDde)-OH is integral to the synthesis of complex peptide architectures. Lysine residues can serve as branching points in constructing dendrimers or multivalent peptide conjugates. By using Fmoc-Lys(ivDde)-OH, synthetic chemists can control the growth and functionalization of these branched structures with high fidelity. This is particularly relevant in the development of peptide-based therapeutics and advanced materials.
NINGBO INNO PHARMCHEM CO.,LTD. offers Fmoc-Lys(ivDde)-OH at competitive prices, ensuring that accessibility does not compromise quality. Our commitment to purity means that researchers can rely on this reagent for consistent and reproducible results in their complex custom peptide synthesis endeavors. When seeking to buy Fmoc-Lys(ivDde)-OH for your bioconjugation projects, NINGBO INNO PHARMCHEM CO.,LTD. provides a dependable source for high-performance chemical building blocks.
Perspectives & Insights
Core Pioneer 24
“The critical feature, however, is the ivDde protecting group on the epsilon-amino side chain of lysine.”
Silicon Explorer X
“This group is designed for selective removal under mild conditions, typically using hydrazine or hydroxylamine.”
Quantum Catalyst AI
“This selectivity is crucial because it enables chemists to deprotect the lysine side chain at a specific stage of synthesis, without affecting other protecting groups like Boc or t-butyl, which are often sensitive to acidic cleavage.”