Bicuculline, a fascinating alkaloid with the CAS number 485-49-4, has carved a significant niche in the scientific community, particularly within neuroscience and pharmacology. Its defining characteristic is its potent activity as a competitive antagonist of GABA(A) receptors. This interaction is crucial because GABA, or gamma-aminobutyric acid, is the principal inhibitory neurotransmitter in the mammalian central nervous system. By blocking GABA's binding to its receptors, Bicuculline effectively disinhibits neuronal activity, leading to increased excitation.

The structural elucidation and functional characterization of Bicuculline have revealed it to be a benzylisoquinoline alkaloid. Initially isolated from plant sources, its consistent pharmacological profile has made it a reliable tool for researchers. The ability to purchase Bicuculline from specialized chemical suppliers ensures that scientists have access to a high-quality reagent for their experiments. The price of Bicuculline can vary based on purity and quantity, but its scientific value often outweighs the cost for critical research applications.

The applications of Bicuculline are diverse and impactful. In neuropharmacology, it is indispensable for studying the role of GABAergic inhibition in synaptic plasticity, learning, and memory. Researchers use Bicuculline to differentiate GABA(A) receptor-mediated responses from other neurotransmitter systems. Its use in modeling neurological conditions is extensive; for instance, it is a standard agent for inducing seizure-like activity in brain slices, which is vital for understanding the pathophysiology of epilepsy and for testing new antiepileptic drugs. The buy decisions for Bicuculline are often driven by its established efficacy in these experimental paradigms.

Furthermore, Bicuculline has been explored for its potential in understanding and treating various CNS disorders. Its stimulant properties, arising from disinhibition, have led to investigations into its effects on mood and behavior. The ongoing research into Bicuculline highlights its importance as a fine chemical and a pharmaceutical intermediate. As scientists continue to unravel the complexities of the brain, the demand for such well-characterized pharmacological tools remains high.

For those involved in scientific research, understanding the sources and availability of Bicuculline is key. Whether looking for small research quantities or larger amounts for more extensive studies, identifying reputable suppliers is essential. The scientific literature frequently cites the use of Bicuculline, underscoring its consistent contribution to advancing our knowledge of neural signaling. The accessibility and reliable supply of Bicuculline are critical for the progress of neuroscience.