The Science Behind Polyethylene Glycol 4000 as a Pharmaceutical Excipient
At NINGBO INNO PHARMCHEM CO.,LTD., we pride ourselves on supplying chemicals that form the backbone of advanced pharmaceutical preparations. Polyethylene Glycol 4000 (PEG 4000) is one such critical ingredient. Its specific chemical structure and physical properties make it an exceptionally versatile pharmaceutical excipient, enabling formulators to achieve desired drug delivery profiles and product stability.
The chemical identity of PEG 4000 is that of a polymer of ethylene oxide, represented by the formula H−(O−CH2−CH2)n−OH, where 'n' indicates the average number of repeating ethylene oxide units. With an average molecular weight between 3600 and 4400 Daltons, PEG 4000 falls into the category of high molecular weight polyethylene glycols. This higher molecular weight contributes to its solid-state properties at room temperature, typically appearing as white or almost white solid flakes or powder. Its purity, often exceeding 99%, is a testament to the rigorous manufacturing processes employed, ensuring it meets the exacting standards for pharmaceutical grade polyethylene glycol 4000.
The scientific application of PEG 4000 as a pharmaceutical excipient is extensive. In tablet formulations, it acts as a binder, enhancing the mechanical strength of the tablet. This binding capability is crucial for creating robust dosage forms that can withstand the rigors of manufacturing and distribution. Beyond physical integrity, PEG 4000 is instrumental in modifying drug release. Its hydrophilic nature means it readily interacts with physiological fluids, influencing the rate at which an active pharmaceutical ingredient dissolves and becomes available for absorption. Understanding these high molecular weight PEG applications allows formulators to design drugs with specific therapeutic actions, from rapid release to sustained delivery.
Moreover, PEG 4000 finds utility as an ointment bulk material and lubricant. Its semi-solid, waxy consistency at slightly elevated temperatures, coupled with its biocompatibility, makes it a suitable base for topical preparations. It helps to create smooth, stable ointments and creams, ensuring even application and effective delivery of topical medications. The ability to buy polyethylene glycol 4000 online from reputable sources like NINGBO INNO PHARMCHEM CO.,LTD. simplifies the procurement process for these essential ingredients.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing the pharmaceutical industry with excipients of exceptional quality. Our Polyethylene Glycol 4000 is manufactured under strict quality control protocols, ensuring lot-to-lot consistency and purity. We believe that by supplying high-caliber PEG 4000 excipient, we contribute to the development of safer, more effective, and reliable pharmaceutical products worldwide. Partner with us to leverage the scientific advantages of PEG 4000 in your next formulation.
Perspectives & Insights
Future Origin 2025
“With an average molecular weight between 3600 and 4400 Daltons, PEG 4000 falls into the category of high molecular weight polyethylene glycols.”
Core Analyst 01
“This higher molecular weight contributes to its solid-state properties at room temperature, typically appearing as white or almost white solid flakes or powder.”
Silicon Seeker One
“Its purity, often exceeding 99%, is a testament to the rigorous manufacturing processes employed, ensuring it meets the exacting standards for pharmaceutical grade polyethylene glycol 4000.”