NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality chemical compounds that drive innovation in research and development. Among these, O-tert-Butyl-L-serine (CAS 18822-58-7) stands out as a critical intermediate with significant applications, particularly in the field of organic synthesis and biochemistry.

This compound is a derivative of the essential amino acid L-serine, modified with a tert-butyl ether group attached to the hydroxyl side chain. This protective modification is crucial for its utility. Chemically, O-tert-Butyl-L-serine has the molecular formula C7H15NO3 and a molecular weight of 161.20. It typically presents as a white powder, a common form for many organic intermediates used in laboratories. The presence of the bulky tert-butyl group enhances its hydrophobicity, distinguishing it from its parent amino acid and influencing its solubility and reactivity in various chemical environments.

The primary application driving the demand for O-tert-Butyl-L-serine is its role in peptide synthesis. In modern peptide synthesis, particularly solid-phase peptide synthesis (SPPS), temporary protection of amino acid side chains is essential to ensure the correct sequence and prevent undesired side reactions. The tert-butyl ether on serine is a widely used protecting group due to its stability under the typical coupling conditions used in SPPS and its reliable cleavage under acidic treatment (e.g., using trifluoroacetic acid) during the final stages of synthesis. This protection mechanism is vital for the successful synthesis of complex peptides, including those with modified structures like glycopeptides and lipopeptides. NINGBO INNO PHARMCHEM CO.,LTD. provides researchers with this critical building block, ensuring consistent purity and performance.

Beyond peptide synthesis, O-tert-Butyl-L-serine is also a valuable component in medicinal chemistry research. As a building block, it can be incorporated into novel molecules to explore structure-activity relationships (SAR) and to impart specific properties. The tert-butyl group can influence a molecule's lipophilicity, metabolic stability, and interaction with biological targets, making it a strategic choice for drug design. The precise synthesis and consistent quality of this compound are therefore paramount for researchers engaged in drug discovery and development.

In essence, O-tert-Butyl-L-serine (CAS 18822-58-7) is a cornerstone research chemical that facilitates complex synthetic strategies. Its importance in peptide synthesis and its utility in medicinal chemistry underscore its value to the scientific community. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting these critical research endeavors by ensuring the availability of high-quality O-tert-Butyl-L-serine, thereby contributing to advancements in chemistry and its applications.