Exploring the Applications of SMCC: From Bioconjugation to Chemical Research
NINGBO INNO PHARMCHEM CO.,LTD. is a leading provider of specialized chemical compounds that facilitate cutting-edge scientific research and development. Among our extensive catalog, Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) stands out for its versatility and importance across multiple scientific disciplines. This heterobifunctional crosslinker is instrumental in various bioconjugation techniques and a broad spectrum of chemical research applications.
The core utility of SMCC lies in its ability to create covalent linkages between molecules containing different reactive groups. Specifically, it possesses an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive maleimide moiety. This dual reactivity allows researchers to precisely link molecules that might otherwise be incompatible. For instance, in proteomics and biochemical research, SMCC is used to crosslink proteins, study protein-protein interactions, or conjugate proteins to labels or surfaces. The stability afforded by its cyclohexane spacer arm ensures that these linkages remain robust under various experimental conditions.
In the field of diagnostics and imaging, SMCC plays a significant role in labeling antibodies or other biomolecules with reporter molecules like fluorophores or chelating agents for radiolabeling. This precise modification is critical for developing sensitive diagnostic assays and targeted imaging agents. The ease with which SMCC can be incorporated into conjugation strategies makes it a preferred reagent for many laboratories. Its membrane permeability also opens possibilities for intracellular protein crosslinking, a valuable technique for studying cellular mechanisms and drug targets.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting scientific discovery by providing high-purity SMCC. We understand that the success of research often hinges on the quality of the reagents used. Our commitment to excellence ensures that our SMCC product meets the stringent requirements for sensitive biochemical assays and complex bioconjugation protocols. Whether you are working in academic research, biotechnology, or pharmaceutical development, SMCC offers a reliable solution for your molecular linking needs. We also offer custom synthesis services, allowing researchers to obtain SMCC or derivatives tailored to specific experimental designs. Trust NINGBO INNO PHARMCHEM CO.,LTD. for your critical chemical supply needs.
Perspectives & Insights
Bio Analyst 88
“This precise modification is critical for developing sensitive diagnostic assays and targeted imaging agents.”
Nano Seeker Pro
“The ease with which SMCC can be incorporated into conjugation strategies makes it a preferred reagent for many laboratories.”
Data Reader 7
“Its membrane permeability also opens possibilities for intracellular protein crosslinking, a valuable technique for studying cellular mechanisms and drug targets.”