NINGBO INNO PHARMCHEM CO.,LTD. is a trusted source for high-quality chemicals that underpin advancements in chemical synthesis and scientific research. Among our key products is Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, widely known as SMCC. This compound is a highly effective heterobifunctional crosslinker, essential for a wide array of molecular conjugation and modification tasks.

SMCC is characterized by its two distinct reactive groups, strategically placed on either end of a stable cyclohexane spacer arm. The NHS ester component readily reacts with primary amines, forming stable amide bonds. This reaction is typically carried out at a neutral to slightly alkaline pH. The other end of the molecule features a maleimide group, which exhibits a strong affinity for sulfhydryl (thiol) groups, forming a robust thioether bond. This maleimide-sulfhydryl reaction is often performed at a slightly acidic to neutral pH. The orthogonal reactivity of these two groups allows for selective and sequential conjugation, a critical feature in complex chemical synthesis and bioconjugation strategies.

The stability imparted by the cyclohexane ring in SMCC is a significant advantage, particularly when compared to crosslinkers with more flexible aliphatic chains. This structural feature enhances the overall stability of the maleimide group, making SMCC a reliable choice for applications where conjugate integrity is paramount. Researchers leverage SMCC for various purposes, including the synthesis of antibody-drug conjugates (ADCs), the labeling of proteins with enzymes or fluorescent tags, and the immobilization of biomolecules onto solid supports or surfaces. Its utility also extends to creating new materials with tailored properties.

As a leading supplier of research chemicals, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our SMCC product is manufactured to high standards of purity and consistency. This reliability is crucial for obtaining reproducible results in sensitive chemical synthesis and research experiments. We are dedicated to supporting the scientific community by providing access to essential chemical tools like SMCC, enabling groundbreaking discoveries and the development of innovative technologies. Whether your work involves intricate organic synthesis, advanced bioconjugation, or novel material science, SMCC offers a robust and effective solution. Our team is also available to discuss custom synthesis needs, ensuring you have the precise chemical components required for your projects.