In the demanding field of pharmaceutical manufacturing, the selection and sourcing of chemical intermediates are critical steps that directly influence the quality and efficacy of the final drug product. L-tert-Leucine methyl ester hydrochloride, identified by CAS number 63038-27-7, is a key intermediate, particularly recognized for its role in the synthesis of Atazanavir. Sourcing this compound with high purity and consistent quality is paramount for any pharmaceutical company involved in its use.

The primary specification for L-tert-Leucine methyl ester hydrochloride in pharmaceutical applications is its purity, which should ideally be ≥98%. This high purity ensures that unwanted side reactions are minimized and that the final drug product meets stringent regulatory standards. The chemical properties, including its molecular formula (C7H16ClNO2) and molecular weight (181.66000), are well-documented, providing chemists with the necessary information for process development and optimization. Its typical presentation as a white to off-white powder and a low moisture content (≤0.5%) further contribute to its ease of handling and reliable performance.

When sourcing this intermediate, it is essential to partner with reputable suppliers who can guarantee consistent quality and adherence to industry standards. Reliability in supply is also a crucial consideration, as interruptions can significantly impact production schedules and the availability of essential medications. For companies working with Atazanavir synthesis, securing a stable supply of L-tert-Leucine methyl ester hydrochloride is a strategic imperative. The common synonym H-Tle-OMe.HCl pharmaceutical use emphasizes its established role.

Furthermore, understanding the recommended storage conditions, such as -20°C Freezer, is important for maintaining the integrity of the supplied material. Suppliers should provide comprehensive documentation, including Certificates of Analysis (CoA), to verify the purity and specifications of each batch. The detailed chemical properties of CAS 63038-27-7 are vital for process chemists to effectively utilize this compound.

In conclusion, the successful sourcing of L-tert-Leucine methyl ester hydrochloride requires a focus on purity, supplier reliability, and adherence to handling guidelines. As a critical chemical intermediate for HIV drugs, its quality directly impacts the production of life-saving treatments. Pharmaceutical companies must prioritize partnerships that ensure the consistent supply of this high-quality intermediate, thereby supporting the advancement of global health.