For pharmaceutical manufacturers, securing a consistent supply of high-purity intermediates is not just a logistical challenge, but a critical factor in ensuring product quality, regulatory compliance, and manufacturing efficiency. Among these vital compounds, (S)-4-Chloro-3-hydroxybutyronitrile (CAS: 127913-44-4) holds significant importance as a chiral building block for numerous therapeutic agents.

The primary driver for the demand of (S)-4-Chloro-3-hydroxybutyronitrile is its indispensable role in the synthesis of key pharmaceutical precursors. As a crucial intermediate for atorvastatin, a widely used cholesterol-lowering drug, its purity and stereochemical integrity directly influence the efficacy and safety of the final product. Similarly, its application in the preparation of hydroxypyrrolidinones, precursors to carbapenem antibiotics, further highlights its significance in producing life-saving medications. Pharmaceutical companies must therefore prioritize sourcing this material from reliable manufacturers who adhere to stringent quality control measures.

When sourcing (S)-4-Chloro-3-hydroxybutyronitrile, several factors should be carefully considered. Firstly, the purity of the compound is paramount. Technical specifications often indicate a purity of 95% or higher, but for pharmaceutical applications, even greater scrutiny may be required. Optical purity, often expressed as enantiomeric excess (ee), is equally critical for chiral intermediates. A high optical purity ensures that the desired enantiomer is predominantly present, minimizing the risk of unwanted side products or reduced therapeutic effect.

Secondly, the reliability of the supplier is a key consideration. Manufacturers often look for suppliers who can provide comprehensive documentation, including Certificates of Analysis (CoA), Safety Data Sheets (SDS), and, where applicable, GMP compliance information. Building a relationship with a supplier that can guarantee consistent quality, batch-to-batch reproducibility, and timely delivery is essential for uninterrupted production cycles. Exploring options to purchase (S)-4-Chloro-3-hydroxybutyronitrile from established chemical suppliers in China, known for their robust manufacturing capabilities, is a common strategy.

The pricing of (S)-4-Chloro-3-hydroxybutyronitrile can vary depending on the quantity, purity, and supplier. For research and development purposes, smaller quantities may be purchased, while larger-scale manufacturing will require bulk orders. Comparing prices from multiple reputable sources, and potentially requesting a free sample for initial quality assessment, can help optimize procurement strategies. Understanding the market price for such intermediates is also crucial for accurate cost projections in drug development.

In conclusion, (S)-4-Chloro-3-hydroxybutyronitrile is a cornerstone intermediate for the synthesis of critical pharmaceuticals. Pharmaceutical manufacturers must approach its sourcing with a strategic mindset, focusing on purity, supplier reliability, and cost-effectiveness. By carefully selecting their partners and understanding the product's specifications, companies can ensure the successful and efficient production of essential medicines, contributing to global health advancements.