NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to advancing drug discovery through the meticulous study of structure-activity relationships (SAR). The thieno[3,2-d]pyrimidine scaffold, particularly derivatives like 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine (CAS 41102-25-4), offers a rich platform for such investigations. Understanding how specific structural features influence biological outcomes is crucial for designing more effective and targeted therapeutics.

The SAR of thieno[3,2-d]pyrimidine derivatives is complex and highly dependent on the nature and position of substituents. For 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine, the presence of halogen atoms is particularly significant. Bromine at the C7 position and chlorine atoms at C2 and C4 are known to enhance lipophilicity and engage in halogen bonding, which can improve binding affinity to biological targets such as enzymes or receptors. For instance, research has shown that introducing bromine at the 7-position of the thieno[3,2-d]pyrimidine ring can substantially increase its antiproliferative activity against cancer cell lines. Similarly, modifications at the pyrimidine ring can influence metabolic stability and oral bioavailability.

The role of 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine as a versatile intermediate allows chemists to systematically explore these SAR principles. By performing various coupling reactions on the bromo and chloro substituents, researchers can introduce a wide array of chemical groups and evaluate their impact on biological activity. This approach has led to the identification of thieno[3,2-d]pyrimidine analogs with potent anticancer and antimicrobial properties. For example, modifications that enhance selectivity towards specific kinases or disrupt essential microbial pathways are actively pursued. The medicinal chemistry applications stemming from these SAR studies are vast, paving the way for novel drug development.

At NINGBO INNO PHARMCHEM CO.,LTD., we provide researchers with high-purity intermediates like CAS 41102-25-4, enabling them to conduct detailed SAR studies. Our commitment to quality ensures that the results obtained from experiments using our products are reliable and reproducible. By facilitating the synthesis of diverse thieno[3,2-d]pyrimidine analogs, we aim to accelerate the discovery of new medicines and contribute to advancements in pharmaceutical science.