NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to advancing scientific discovery by providing essential chemical reagents and intermediates. Among these, 1-Boc-3-hydroxymethylpyrrolidine, identified by its CAS number 114214-69-6, stands out for its significant role in advanced chemical research and synthesis.

The synthesis of 1-Boc-3-hydroxymethylpyrrolidine typically involves the protection of the nitrogen atom in 3-hydroxymethylpyrrolidine with a tert-butoxycarbonyl (Boc) group. This is commonly achieved by reacting 3-hydroxymethylpyrrolidine with di-tert-butyl dicarbonate in the presence of a base. The reaction is generally efficient, yielding the product with high purity, often exceeding 98.0% (GC), as supplied by NINGBO INNO PHARMCHEM CO.,LTD. This high purity is critical for subsequent synthetic steps, ensuring minimal interference from byproducts.

The versatility of 1-Boc-3-hydroxymethylpyrrolidine as a chemical intermediate stems from its functional groups. The Boc group can be readily removed under acidic conditions, revealing the secondary amine for further functionalization. Simultaneously, the primary alcohol group can undergo various transformations, such as oxidation, esterification, or etherification. This dual reactivity makes it an attractive building block for constructing complex organic molecules, including pharmaceuticals and specialty chemicals.

A prominent application of 1-Boc-3-hydroxymethylpyrrolidine is in the synthesis of SR 9009, a molecule that modulates REV-ERB nuclear receptors and has shown potential in treating metabolic disorders and sleep-related issues. Researchers aiming to synthesize SR 9009 or similar compounds often need to buy 1-Boc-3-hydroxymethylpyrrolidine as a reliable starting material.

NINGBO INNO PHARMCHEM CO.,LTD. provides not only this key intermediate but also supports researchers by offering comprehensive product data and reliable supply chains. The company’s commitment to quality ensures that scientists can access the pharmaceutical intermediates they need for their demanding research projects, contributing to breakthroughs in various scientific disciplines. The consistent availability and high quality of 1-Boc-3-hydroxymethylpyrrolidine from NINGBO INNO PHARMCHEM CO.,LTD. make it an indispensable reagent for modern chemical research.