In the realm of organic chemistry and pharmaceutical manufacturing, understanding the synthesis and properties of key intermediates is crucial for efficient production and innovation. 2-Chloro-4-pyridinecarboxylic acid (CAS 6313-54-8) is one such compound that holds significant importance as a versatile intermediate in various chemical processes.

The synthesis of 2-Chloro-4-pyridinecarboxylic acid often involves several steps, starting from more basic pyridine precursors. One common approach involves the chlorination of isonicotinic acid or its derivatives, followed by selective modifications. For example, a typical route might involve reacting isoniacin with a chlorinating agent to produce a dichlorinated intermediate, which is then subjected to a directed dechlorination process to yield the desired 2-chloro-4-pyridinecarboxylic acid. These multi-step syntheses require precise control over reaction conditions, including temperature, pressure, and reagent concentrations, to ensure high yields and purity.

Chemically, 2-Chloro-4-pyridinecarboxylic acid is characterized by its molecular formula C6H4ClNO2 and a molecular weight of 157.55. It typically appears as a white to beige crystalline powder, with a melting point of approximately 246 °C (with decomposition). Its solubility profile indicates it is slightly soluble in water and ethanol, and insoluble in ether. The pyridine ring, with its electron-deficient nature, allows for various nucleophilic substitution reactions, especially with strong nucleophiles. The presence of the chlorine atom and the carboxylic acid group provides dual functionality, enabling it to participate in a wide range of organic transformations.

The primary application of 2-Chloro-4-pyridinecarboxylic acid is as an intermediate in the pharmaceutical industry. Its structural features make it an ideal building block for synthesizing more complex drug molecules. It has been noted in scientific literature for its use in creating derivatives of camptothecin, which are investigated for their anticancer properties. This highlights its value in medicinal chemistry and drug discovery, particularly in the development of targeted therapies.

For companies seeking to procure this chemical, understanding its synthesis and properties is key to ensuring optimal use. Manufacturers often provide detailed technical specifications, including purity levels (e.g., u2265 99.0%) and physical characteristics. These specifications are vital for ensuring that the intermediate performs as expected in subsequent synthetic steps, contributing to the efficiency and success of the overall manufacturing process. Sourcing from reputable suppliers in China ensures access to a reliable supply of this important compound.

In summary, 2-Chloro-4-pyridinecarboxylic acid is a crucial fine chemical intermediate with a well-defined synthesis pathway and valuable chemical properties. Its role in pharmaceutical synthesis, particularly in the development of anticancer drugs, underscores its significance in the broader field of chemical innovation.