At NINGBO INNO PHARMCHEM CO.,LTD., a deep understanding of chemical synthesis and properties is at the core of our operations. 2-Phenylethylamine Hydrochloride (CAS 156-28-5) is a compound whose synthesis and characteristics are fundamental to its widespread applications. This article outlines the common methods for producing this vital organic intermediate and details its key properties.

The synthesis of 2-Phenylethylamine Hydrochloride typically involves several established organic chemistry routes. One common pathway begins with the reduction of benzyl cyanide. This reaction, often carried out using hydrogen in the presence of a catalyst like Raney-Nickel under specific temperature and pressure conditions, yields 2-phenylethylamine. Subsequent treatment with hydrochloric acid converts the amine into its more stable hydrochloride salt, resulting in the desired product. Alternative methods may involve the reduction of ω-nitrostyrene using reducing agents such as lithium aluminum hydride, offering another effective route to synthesize the phenethylamine structure.

Understanding the CAS 156-28-5 chemical properties is essential for its handling and application. 2-Phenylethylamine Hydrochloride typically presents as a white powder. It exhibits good solubility in water, and also in solvents like ethanol and ether, which is advantageous for various reaction and formulation processes. Its melting point generally falls within the range of 220-224°C, indicating a stable crystalline structure.

As a hydrochloride salt, the compound is acidic in nature. Its stability under neutral or acidic conditions makes it suitable for a range of chemical reactions where pH control is important. The molecular formula is C8H12ClN, with a molecular weight of approximately 157.64 g/mol. These specifications are critical for chemists involved in fine chemical synthesis and the development of new chemical entities.

The reliability of the synthesis of 2-Phenylethylamine Hydrochloride directly impacts its purity and efficacy in downstream applications. At NINGBO INNO PHARMCHEM CO.,LTD., we employ stringent quality control measures throughout our manufacturing process to ensure that our 2-Phenylethylamine Hydrochloride meets the highest purity standards, providing our clients with a dependable intermediate for their complex chemical synthesis needs.