Biochemical research often relies on specific molecular tools that can precisely target and modulate biological pathways. Cerulenin, a compound with the CAS number 17397-89-6, is a prime example of such a tool, recognized for its potent inhibitory effects on fatty acid and polyketide biosynthesis. Its classification as an irreversible inhibitor of fatty acid synthase (FASN) makes it indispensable for understanding the intricate details of lipid metabolism, a process critical for cell structure, energy storage, and signaling.

The molecular mechanism of Cerulenin's action is well-defined: it targets the beta-ketoacyl-ACP synthase (KAS) enzyme, a critical component of the FASN complex. Through covalent modification of a cysteine residue in the KAS active site, Cerulenin permanently inactivates the enzyme. This irreversible inhibition leads to a cascade of effects, most notably the cessation of de novo fatty acid synthesis. This has profound implications for cellular function, as fatty acids are vital for the production of phospholipids, which form the lipid bilayer of cell membranes, and for energy storage in the form of triglycerides. Disruption of these processes can significantly impact cell growth, proliferation, and survival.

Beyond its well-studied role as a FASN inhibitor, Cerulenin also exhibits notable antibiotic properties. This suggests that fatty acid synthesis pathways, and specifically the enzymes targeted by Cerulenin, are essential for the viability of certain microorganisms. Its efficacy as an antibiotic provides a dual utility, allowing researchers to investigate both mammalian and microbial lipid metabolism. The study of Cerulenin's chemical synthesis and its purification are crucial steps in ensuring its availability as a high-purity biochemical for research purposes. For laboratories interested in exploring these areas, knowing where to buy Cerulenin is a key consideration.

The broad applicability of Cerulenin extends to various research fields, including cancer biology, where FASN overexpression is a common hallmark, and metabolic syndrome research. By providing a reliable method to inhibit fatty acid synthesis, Cerulenin aids in the development of targeted therapies and a deeper understanding of metabolic diseases. The continued exploration of Cerulenin's biochemical significance highlights its enduring value as a research reagent.