The Chemical Profile of 4-(2-Bromoacetyl)benzonitrile: Properties and Applications
Understanding the precise chemical and physical properties of a pharmaceutical intermediate is fundamental to its effective utilization in synthesis. 4-(2-Bromoacetyl)benzonitrile (CAS: 20099-89-2) is one such compound whose characteristics make it highly valuable in the pharmaceutical industry, particularly as an intermediate for antifungal agents like Isavuconazole. NINGBO INNO PHARMCHEM CO.,LTD. provides this essential compound, adhering to detailed specifications.
Chemically, 4-(2-Bromoacetyl)benzonitrile is characterized by its molecular formula C9H6BrNO and a molecular weight of 224.05. Physically, it typically presents as an off-white to light yellow crystalline powder. Its melting point range is generally between 92-96 °C, and it exhibits solubility in common organic solvents like methanol. The presence of both a reactive alpha-bromo ketone and a nitrile group within the same molecule provides significant synthetic flexibility.
These chemical properties are key to its role as a pharmaceutical synthesis intermediate. The bromoacetyl group is highly electrophilic and readily undergoes nucleophilic substitution reactions, enabling the formation of new chemical bonds essential for building complex drug molecules. This reactivity is exploited in the synthesis of Isavuconazole, where it forms a critical part of the molecule's structure.
Beyond its direct application in antifungal drug synthesis, 4-(2-Bromoacetyl)benzonitrile is also recognized for its potential in research as a Glycogen synthase kinase 3 (GSK-3) inhibitor. This dual utility makes it a sought-after compound for laboratories engaged in drug discovery and development. For those looking to buy 4-(2-Bromoacetyl)benzonitrile online, NINGBO INNO PHARMCHEM CO.,LTD. offers a reliable source, ensuring the quality needed for both research and large-scale production.
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing detailed technical information and high-purity intermediates like 4-(2-Bromoacetyl)benzonitrile to support the advancements in medicinal chemistry and pharmaceutical manufacturing. Our commitment ensures that researchers and producers have access to the building blocks necessary for innovation.
Perspectives & Insights
Core Pioneer 24
“The bromoacetyl group is highly electrophilic and readily undergoes nucleophilic substitution reactions, enabling the formation of new chemical bonds essential for building complex drug molecules.”
Silicon Explorer X
“This reactivity is exploited in the synthesis of Isavuconazole, where it forms a critical part of the molecule's structure.”
Quantum Catalyst AI
“Beyond its direct application in antifungal drug synthesis, 4-(2-Bromoacetyl)benzonitrile is also recognized for its potential in research as a Glycogen synthase kinase 3 (GSK-3) inhibitor.”