Understanding the precise chemical profile of a compound is crucial for its effective utilization in synthesis and manufacturing. (S)-(+)-2-Amino-3-methyl-1-butanol, identified by CAS 2026-48-4 and commonly known as L-Valinol, is a chiral amino alcohol with a distinct set of properties that make it highly valuable. NINGBO INNO PHARMCHEM CO.,LTD. offers this compound and shares insights into its chemical characteristics and applications.

L-Valinol typically presents as a white to light yellow crystal powder with a purity often exceeding 99%. Its molecular formula is C5H13NO, with a molecular weight of approximately 103.16 g/mol. The compound possesses a melting point range typically between 30-34°C, meaning it can exist as a solid or a liquid depending on ambient temperature. Its boiling point is recorded around 81°C at 8 mm Hg. The specific rotation ([α]25/D) is typically around +10°, indicating its dextrorotatory nature, which is vital for its use in chiral synthesis.

Chemically, L-Valinol is characterized by the presence of both an amine group (-NH2) and a hydroxyl group (-OH). These functional groups allow it to participate in a wide range of reactions. The amine group can undergo acylation, alkylation, and form imines with aldehydes. The hydroxyl group can be esterified, etherified, or oxidized. Its bifunctional nature, combined with its chirality, makes it an exceptionally useful building block for constructing complex molecules. For example, it is employed in the synthesis of chiral oxazoline derivatives, which are important ligands in catalysis.

The applications of L-Valinol are predominantly centered around its role as a pharmaceutical intermediate and a chiral building block in advanced organic synthesis. It is a key component in the synthesis of enantiomerically pure compounds, including intermediates for drugs used in treating cancer (e.g., MDM2 inhibitors) and cardiovascular conditions. Its use ensures the stereochemical integrity of the final active pharmaceutical ingredients (APIs), which is critical for therapeutic efficacy and safety.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical intermediates that meet the rigorous demands of the pharmaceutical and fine chemical industries. Our L-Valinol (CAS 2026-48-4) is supplied with guaranteed purity and precise stereochemistry, supporting our clients in their critical synthesis and manufacturing endeavors. By understanding the detailed chemical profile of L-Valinol, researchers and manufacturers can unlock its full potential in developing innovative chemical solutions.